Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 13/20 | 0.65 |
| ▸ | MET | P08581 | 2/20 | 0.65 |
| ▸ | CDK7 | P50613 | 3/20 | 0.64 |
| ▸ | CDK9 | P50750 | 2/20 | 0.64 |
| ▸ | PTK2 | Q05397 | 5/20 | 0.62 |
| ▸ | AXL | P30530 | 2/20 | 0.60 |
| ▸ | INSR | P06213 | 2/20 | 0.60 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.60 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.60 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.60 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.60 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.60 |
| ▸ | PLK4 | O00444 | 1/20 | 0.60 |
| ▸ | STK25 | O00506 | 1/20 | 0.60 |
| ▸ | RIOK3 | O14730 | 1/20 | 0.60 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.60 |
| ▸ | CASK | O14936 | 1/20 | 0.60 |
| ▸ | AURKA | O14965 | 1/20 | 0.60 |
| ▸ | GAK | O14976 | 1/20 | 0.60 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24073738 | 1.00 | ALK (0.65) | ALKMETCDK7CDK9PTK2 | |
| SCHEMBL25834898 | 0.92 | AXL (0.63) | ALKMETCDK7CDK9AXL | |
| SCHEMBL30266655 | 0.92 | AXL (0.63) | ALKMETCDK7CDK9AXL | |
| SCHEMBL24073478 | 0.92 | AXL (0.63) | ALKMETCDK7CDK9AXL | |
| SCHEMBL30266607 | 0.90 | AXL (0.57) | ALKMETCDK7CDK9PTK2 | |
| SCHEMBL24073509 | 0.90 | AXL (0.60) | ALKMETCDK7CDK9PTK2 | |
| SCHEMBL24073719 | 0.90 | ALK (0.65) | ALKMETCDK7CDK9PTK2 | |
| SCHEMBL25834871 | 0.90 | ALK (0.65) | ALKMETCDK7CDK9PTK2 | |
| SCHEMBL25834975 | 0.90 | AXL (0.60) | ALKMETCDK7CDK9PTK2 | |
| SCHEMBL24073715 | 0.90 | AXL (0.63) | ALKMETCDK7CDK9PTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230227484-A1 | PYRIMIDINE COMPOUND AS AXL INHIBITOR | NANJING CHIA TAI TIANQING PHARMACEUTICAL CO., LTD. (CN) | 2023-07-20 | — | — | US | disclosed |
| US-20230227484-A1 | PYRIMIDINE COMPOUND AS AXL INHIBITOR | NANJING CHIA TAI TIANQING PHARMACEUTICAL CO., LTD. (CN) | 2023-07-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230227484-A1 | PYRIMIDINE COMPOUND AS AXL INHIBITOR | AXL, FLT3, TYMP | ALK 87/4885MET 356/4885CDK7 88/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.