SCHEMBL25836778

SCHEMBL25836778

COCCC1(CCOC)c2cc(-c3ccc(C(F)(F)F)cc3)ccc2-c2c1cc(O)c1cc(OC)c(OC)cc21

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TDO2 P48775 2/20 0.36
IDO1 P14902 1/20 0.36
KIF11 P52732 1/20 0.35
MCHR1 Q99705 4/20 0.35
AKR1C3 P42330 1/20 0.34
AKR1C2 P52895 1/20 0.34
MGAM O43451 3/20 0.34
GAA P10253 3/20 0.34
SI P14410 3/20 0.34
MGAM2 Q2M2H8 3/20 0.34
CYP1A1 P04798 2/20 0.32
CYP1B1 Q16678 2/20 0.32
SLC6A2 P23975 1/20 0.32
P2RY14 Q15391 1/20 0.32
ALOX5AP P20292 2/20 0.32
FEN1 P39748 2/20 0.32
PDK2 Q15119 2/20 0.32
CNR1 P21554 1/20 0.31
CNR2 P34972 1/20 0.31
DUSP3 P51452 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25836793 0.93 KCNH2 (0.35) AKR1C3AKR1C2GAACYP1A1CYP1B1
SCHEMBL25875873 0.90 IDO1 (0.36) TDO2IDO1KIF11MCHR1AKR1C3
SCHEMBL1816876 0.83 IDO1 (0.39) TDO2IDO1KIF11MCHR1AKR1C3
SCHEMBL25875887 0.83 KCNH2 (0.35) GAACYP1A1CYP1B1CNR1CNR2
SCHEMBL25876749 0.79 PDK2 (0.37) AKR1C3AKR1C2MGAMGAASI
SCHEMBL25837296 0.79 PDK2 (0.35) GAAPDK2
SCHEMBL25836787 0.78 ALK (0.34)
SCHEMBL31407853 0.76 SLC6A2 (0.35) KIF11SLC6A2P2RY14PDK2
SCHEMBL27165408 0.76 SLC6A2 (0.35) KIF11SLC6A2P2RY14PDK2
SCHEMBL1815597 0.75 KCNH2 (0.36) TDO2IDO1AKR1C3AKR1C2GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023136213-A1 PHOTOCHROMIC COMPOUND, NAPHTHOL DERIVATIVE, CURABLE COMPOSITION, OPTICAL ARTICLE, LENS, AND EYEGLASSES 株式会社トクヤマ 2023-07-20 WO disclosed