Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.43 |
| ▸ | ACACB | O00763 | 1/20 | 0.39 |
| ▸ | WDR91 | A4D1P6 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 4/20 | 0.35 |
| ▸ | DRD4 | P21917 | 3/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.35 |
| ▸ | CCR1 | P32246 | 1/20 | 0.34 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.33 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL895492 | 1.00 | NOTUM (0.43) | NOTUMACACBWDR91MEN1ALDH1A1 | |
| SCHEMBL895493 | 1.00 | NOTUM (0.43) | NOTUMACACBWDR91MEN1ALDH1A1 | |
| SCHEMBL894373 | 1.00 | NOTUM (0.43) | NOTUMACACBWDR91MEN1ALDH1A1 | |
| SCHEMBL894372 | 1.00 | NOTUM (0.43) | NOTUMACACBWDR91MEN1ALDH1A1 | |
| SCHEMBL10207359 | 0.89 | NOTUM (0.38) | NOTUMACACBWDR91MEN1ALDH1A1 | |
| SCHEMBL894851 | 0.82 | KDM4E (0.43) | MEN1ALDH1A1MAPTKMT2ADRD2 | |
| SCHEMBL894775 | 0.78 | NOTUM (0.38) | NOTUMACACBWDR91MEN1ALDH1A1 | |
| SCHEMBL895140 | 0.74 | ALDH1A1 (0.31) | ALDH1A1DRD4 | |
| SCHEMBL10207446 | 0.72 | KDM4E (0.41) | MEN1ALDH1A1MAPTKMT2ADRD2 | |
| SCHEMBL2576600 | 0.72 | CHRM4 (0.38) | ALDH1A1DRD2DRD3THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2560978-A1 | INHIBITORS OF ARGINASE AND THEIR THERAPEUTIC APPLICATIONS | Mars, Incorporated (US) | 2013-02-27 | — | — | EP | disclosed |
| WO-2011133653-A1 | INHIBITORS OF ARGINASE AND THEIR THERAPEUTIC APPLICATIONS | MARS, INCORPORATED (US) | 2011-10-27 | — | — | WO | disclosed |