SCHEMBL2583781

SCHEMBL2583781

C[C@@]1(C(=O)O)CCCN1C(=O)OCC1c2ccccc2-c2ccccc21

nearest known ligand 0.43

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
EPHX2 P34913 1/20 0.43
FABP5 Q01469 3/20 0.42
FABP7 O15540 2/20 0.42
KMT2A Q03164 2/20 0.40
CASP3 P42574 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2583787 1.00 EPHX2 (0.43) EPHX2FABP5FABP7KMT2ACASP3
SCHEMBL30792927 1.00 EPHX2 (0.43) EPHX2FABP5FABP7KMT2ACASP3
SCHEMBL30896020 1.00 EPHX2 (0.43) EPHX2FABP5FABP7KMT2ACASP3
SCHEMBL30016334 1.00 EPHX2 (0.43) EPHX2FABP5FABP7KMT2ACASP3
SCHEMBL18154894 1.00 EPHX2 (0.43) EPHX2FABP5FABP7KMT2ACASP3
SCHEMBL30896027 1.00 EPHX2 (0.43) EPHX2FABP5FABP7KMT2ACASP3
SCHEMBL31742570 0.93 EPHX2 (0.44) EPHX2FABP5FABP7KMT2ACASP3
SCHEMBL28365887 0.85 EPHX2 (0.46) EPHX2FABP5FABP7KMT2ACASP3
SCHEMBL6532381 0.83 CASP3 (0.43) EPHX2KMT2ACASP3
SCHEMBL8120555 0.83 EPHX2 (0.44) EPHX2FABP5FABP7KMT2ACASP3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 88 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4660303-A2 PCSK9 ANTAGONIST COMPOUNDS Merck Sharp & Dohme LLC (US) 2025-12-10 EP disclosed
EP-3810626-B1 PCSK9 ANTAGONIST COMPOUNDS MERCK SHARP & DOHME LLC (US) 2025-07-23 EP disclosed
US-20250206781-A1 PCSK9 ANTAGONIST COMPOUNDS MERCK SHARP & DOHME LLC (US) 2025-06-26 US disclosed
EP-4512818-A1 CYCLIC COMPOUND HAVING SELECTIVE KRAS INHIBITORY EFFECT ON HRAS AND NRAS Chugai Seiyaku Kabushiki Kaisha (JP) 2025-02-26 EP disclosed
US-12209145-B2 PCSK9 antagonist compounds MERCK SHARP & DOHME LLC (US) 2025-01-28 US disclosed
US-12012468-B2 Cyclic polypeptides for PCSK9 inhibition MERCK SHARP & DOHME LLC (US) 2024-06-18 US disclosed
US-20240158446-A1 CYCLIC COMPOUND HAVING SELECTIVE INHIBITORY ACTION ON KRAS OVER HRAS AND NRAS CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2024-05-16 US disclosed
EP-4309741-A1 CYCLIC COMPOUND HAVING INHIBITORY EFFECT SELECTIVE FOR KRAS BUT NOT FOR HRAS AND NRAS CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2024-01-24 EP disclosed
EP-4309741-A1 CYCLIC COMPOUND HAVING INHIBITORY EFFECT SELECTIVE FOR KRAS BUT NOT FOR HRAS AND NRAS CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2024-01-24 EP disclosed
US-20230303625-A1 CYCLIC POLYPEPTIDES FOR PCSK9 INHIBITION RA PHARMACEUTICALS, INC. (US) 2023-09-28 US disclosed
US-20080045461-A1 N-TERMINALLY MODIFIED GLP-1 RECEPTOR MODULATORS BRISTOL-MYERS SQUIBB COMPANY 2008-02-21 US disclosed
US-20080045461-A1 N-TERMINALLY MODIFIED GLP-1 RECEPTOR MODULATORS BRISTOL-MYERS SQUIBB COMPANY 2008-02-21 US disclosed
US-20070238669-A1 HUMAN GLUCAGON-LIKE-PEPTIDE-1 MODULATORS AND THEIR USE IN THE TREATMENT OF DIABETES RELATED CONDITIONS BRISTOL-MYERS SQUIBB COMPANY 2007-10-11 US disclosed
US-20070238669-A1 HUMAN GLUCAGON-LIKE-PEPTIDE-1 MODULATORS AND THEIR USE IN THE TREATMENT OF DIABETES RELATED CONDITIONS BRISTOL-MYERS SQUIBB COMPANY 2007-10-11 US disclosed
WO-2007082264-A2 HUMAN GLUCAGON-LIKE-PEPTIDE-1 MODULATORS AND THEIR USE IN THE TREATMENT OF DIABETES AND RELATED CONDITIONS BRISTOL-MYERS SQUIBB COMPANY (US) 2007-07-19 WO disclosed
US-20070021346-A1 N-terminally modified GLP-1 receptor modulators BRISTOL-MYERS SQUIBB COMPANY 2007-01-25 US disclosed
US-20070021346-A1 N-terminally modified GLP-1 receptor modulators BRISTOL-MYERS SQUIBB COMPANY 2007-01-25 US disclosed
US-7122521-B2 COMPRISING TRIPEPTIDE UNIT OF THE FORMULA (flp-Yaa-Gly)N, WHERE Yaa IS ANY AMINO ACID, FLP IS 4(R)-FLUORO-L-PROLINE, AND N IS AT LEAST 3; INCREASED STABILITY; STRONGER TRIPLE HELIX THAN NATIVE COLLAGEN; FOR USE SUCH AS IN ARTIFICIAL SKIN WISCONSIN ALUMNI RESEARCH FOUNDATION (US) 2006-10-17 US disclosed
WO-2005000872-A2 COLLAGEN MIMICS WISCONSIN ALUMNI RESEARCH FOUNDATION (US) 2005-01-06 WO disclosed
US-20050004032-A1 Collagen mimics NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2005-01-06 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070238669-A1 HUMAN GLUCAGON-LIKE-PEPTIDE-1 MODULATORS AND THEIR USE IN THE TREATMENT OF DIABETES RELATED CONDITIONS GLP1R, GIPR, IAPP EPHX2 3665/4885FABP5 786/4885FABP7 1281/4885
US-20070021346-A1 N-terminally modified GLP-1 receptor modulators GLP1R, GIPR, IAPP EPHX2 4394/4885FABP5 1423/4885FABP7 726/4885
US-20230303625-A1 CYCLIC POLYPEPTIDES FOR PCSK9 INHIBITION PCSK9, LDLR, PCSK7 EPHX2 3480/4885FABP5 689/4885FABP7 992/4885
US-20240158446-A1 CYCLIC COMPOUND HAVING SELECTIVE INHIBITORY ACTION ON KRAS OVER HRAS AND NRAS KRAS, HRAS, NRAS EPHX2 3517/4885FABP5 4703/4885FABP7 4408/4885
US-20080045461-A1 N-TERMINALLY MODIFIED GLP-1 RECEPTOR MODULATORS GLP1R, GIPR, IAPP EPHX2 4375/4885FABP5 1444/4885FABP7 722/4885
US-12012468-B2 Cyclic polypeptides for PCSK9 inhibition PCSK9, LDLR, PCSK7 EPHX2 3480/4885FABP5 689/4885FABP7 992/4885
US-12209145-B2 PCSK9 antagonist compounds PCSK9, PCSK7, PCSK6 EPHX2 2049/4885FABP5 1809/4885FABP7 2407/4885
US-20250206781-A1 PCSK9 ANTAGONIST COMPOUNDS PCSK9, PCSK7, PCSK6 EPHX2 2049/4885FABP5 1809/4885FABP7 2407/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.