Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 6/20 | 0.43 |
| ▸ | TYMS | P04818 | 3/20 | 0.42 |
| ▸ | GART | P22102 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | DRD1 | P21728 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24343434 | 0.93 | TYMS (0.39) | DHFRTYMSGARTFPGS | |
| SCHEMBL25725125 | 0.90 | TYMS (0.41) | DHFRTYMSGARTFPGS | |
| SCHEMBL24343391 | 0.87 | TYMS (0.39) | DHFRTYMSGARTFPGS | |
| SCHEMBL24343431 | 0.83 | DHFR (0.54) | DHFR | |
| SCHEMBL25299028 | 0.83 | DHFR (0.54) | DHFR | |
| SCHEMBL24343426 | 0.82 | DHFR (0.43) | DHFRFPGS | |
| SCHEMBL24344797 | 0.82 | TYMS (0.36) | DHFRTYMSGARTFPGS | |
| SCHEMBL25294343 | 0.82 | TYMS (0.36) | DHFRTYMSGARTFPGS | |
| SCHEMBL25725117 | 0.79 | DHFR (0.53) | DHFR | |
| SCHEMBL24343440 | 0.79 | DHFR (0.43) | DHFRTYMSFPGS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023126297-A1 | ANTIFOLATE LINKER-DRUGS AND ANTIBODY-DRUG CONJUGATES | BYONDIS B.V. (NL) | 2023-07-06 | — | — | WO | disclosed |