Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 2/20 | 0.42 |
| ▸ | JAK3 | P52333 | 2/20 | 0.42 |
| ▸ | ABL1 | P00519 | 3/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | MAP4K1 | Q92918 | 6/20 | 0.37 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.36 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.36 |
| ▸ | IGF1R | P08069 | 3/20 | 0.35 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.35 |
| ▸ | CLK1 | P49759 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.34 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.34 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.34 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21592657 | 0.78 | MAP4K1 (0.50) | JAK2JAK3ABL1MAP4K1MAP3K11 | |
| SCHEMBL25838965 | 0.78 | MAP3K11 (0.52) | ABL1MAP4K1MAP3K11CYP3A4CAMKK2 | |
| SCHEMBL21592549 | 0.76 | MAP4K1 (0.53) | JAK2JAK3MAP4K1MAP3K11CAMKK2 | |
| SCHEMBL28769136 | 0.76 | MAP4K1 (0.54) | JAK2JAK3ABL1MAP4K1MAP3K11 | |
| SCHEMBL31553234 | 0.76 | MAP4K1 (0.54) | JAK2JAK3ABL1MAP4K1MAP3K11 | |
| SCHEMBL21592847 | 0.73 | MAP4K1 (0.61) | JAK2JAK3MAP4K1MAP3K11CAMKK2 | |
| SCHEMBL21592554 | 0.73 | MAP4K1 (0.53) | ABL1MAP4K1MAP3K11CAMKK2DYRK1A | |
| SCHEMBL28502410 | 0.73 | JAK2 (0.44) | JAK2JAK3JAK1CYP3A4CAMKK2 | |
| SCHEMBL30267564 | 0.67 | AXL (0.50) | CYP3A4CAMKK2 | |
| SCHEMBL13941746 | 0.67 | AXL (0.50) | CYP3A4CAMKK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023131122-A1 | FUSED RING-SUBSTITUTED SIX-MEMBERED HETEROCYCLIC COMPOUND, AND PREPARATION METHOD THEREFOR AND USE THEREOF | 劲方医药科技(上海)有限公司 | 2023-07-13 | — | — | WO | disclosed |