Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 12/20 | 0.63 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.63 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.63 |
| ▸ | NEK1 | Q96PY6 | 2/20 | 0.60 |
| ▸ | KIT | P10721 | 1/20 | 0.58 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.58 |
| ▸ | CLK1 | P49759 | 7/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.53 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.53 |
| ▸ | CDK2 | P24941 | 1/20 | 0.53 |
| ▸ | CDK9 | P50750 | 1/20 | 0.53 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.53 |
| ▸ | AXL | P30530 | 1/20 | 0.52 |
| ▸ | CDK8 | P49336 | 1/20 | 0.52 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.52 |
| ▸ | GSK3B | P49841 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20319074 | 0.87 | DYRK1A (0.58) | DYRK1APIK3CANTRK1NEK1KIT | |
| SCHEMBL25785930 | 0.85 | AXL (0.71) | DYRK1ANTRK1NEK1CDK2AXL | |
| SCHEMBL26174749 | 0.84 | NEK1 (0.48) | DYRK1APIK3CANTRK1NEK1KIT | |
| SCHEMBL20319120 | 0.84 | DYRK1A (0.66) | DYRK1APIK3CANTRK1NEK1KIT | |
| SCHEMBL17952128 | 0.84 | NTRK1 (0.62) | DYRK1APIK3CANTRK1NEK1KIT | |
| SCHEMBL19068218 | 0.83 | DYRK1A (0.64) | DYRK1APIK3CANTRK1NEK1KIT | |
| SCHEMBL17951904 | 0.83 | DYRK1A (0.74) | DYRK1APIK3CANTRK1NEK1KIT | |
| SCHEMBL15333224 | 0.83 | DYRK1A (0.74) | DYRK1APIK3CANTRK1NEK1KIT | |
| SCHEMBL25839064 | 0.82 | DYRK1A (0.56) | DYRK1ANTRK1KITDYRK1BCLK1 | |
| SCHEMBL856823 | 0.82 | CDC7 (0.68) | DYRK1APIK3CANTRK1NEK1DYRK1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023131122-A1 | FUSED RING-SUBSTITUTED SIX-MEMBERED HETEROCYCLIC COMPOUND, AND PREPARATION METHOD THEREFOR AND USE THEREOF | 劲方医药科技(上海)有限公司 | 2023-07-13 | — | — | WO | disclosed |