Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 1/20 | 0.38 |
| ▸ | FEN1 | P39748 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.37 |
| ▸ | RXRA | P19793 | 7/20 | 0.37 |
| ▸ | RXRB | P28702 | 6/20 | 0.37 |
| ▸ | RXRG | P48443 | 5/20 | 0.37 |
| ▸ | PTGER1 | P34995 | 3/20 | 0.37 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.34 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.34 |
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2592033 | 0.93 | ALOX5AP (0.38) | ALOX5APFEN1PTGS2RXRARXRB | |
| SCHEMBL14736801 | 0.86 | KDM4E (0.41) | ALOX5APFEN1PTGS2PTGER1HCRTR1 | |
| SCHEMBL7715095 | 0.79 | KDM4E (0.39) | ALOX5APFEN1PTGS2PTGER1HCRTR1 | |
| SCHEMBL2584646 | 0.79 | KDM4E (0.41) | ALOX5APFEN1PTGS2 | |
| SCHEMBL2583872 | 0.76 | KDM4E (0.49) | ALOX5APFEN1PTGS2PTGER1HCRTR1 | |
| SCHEMBL2588544 | 0.76 | MAOA (0.44) | PTGS2PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL2592309 | 0.74 | KDM4E (0.49) | ALOX5APFEN1PTGS2PTGER1HCRTR1 | |
| SCHEMBL2591613 | 0.74 | MAOB (0.39) | ALOX5APFEN1PTGS2PTGER1HCRTR1 | |
| SCHEMBL2581967 | 0.71 | KDM4E (0.38) | ALOX5APFEN1PTGS2 | |
| SCHEMBL2589905 | 0.71 | BRD4 (0.41) | ALOX5APFEN1PTGS2PTGER1HCRTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2563770-A1 | BIARYL PHOSPHODIESTERASE INHIBITORS | Leo Pharma A/S (DK) | 2013-03-06 | — | — | EP | claimed |
| WO-2011134468-A1 | BIARYL PHOSPHODIESTERASE INHIBITORS | LEO PHARMA A/S (DK) | 2011-11-03 | — | — | WO | claimed |
| EP-2563770-A1 | BIARYL PHOSPHODIESTERASE INHIBITORS | Leo Pharma A/S (DK) | 2013-03-06 | — | — | EP | disclosed |
| WO-2011134468-A1 | BIARYL PHOSPHODIESTERASE INHIBITORS | LEO PHARMA A/S (DK) | 2011-11-03 | — | — | WO | disclosed |