Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.63 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.55 |
| ▸ | USP2 | O75604 | 4/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.49 |
| ▸ | NAMPT | P43490 | 1/20 | 0.48 |
| ▸ | GRM5 | P41594 | 1/20 | 0.48 |
| ▸ | PANK3 | Q9H999 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | HBB | P68871 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23544874 | 0.84 | MAPT (0.64) | POLBCYP1A2USP2HSD17B10MAPK1 | |
| SCHEMBL23544868 | 0.83 | NOTUM (0.50) | POLBHSD17B10MAPK1ALDH1A1MAPT | |
| SCHEMBL19701980 | 0.83 | MAPT (0.57) | USP2HSD17B10MAPK1CYP2C19ALDH1A1 | |
| SCHEMBL23446072 | 0.83 | POLB (0.67) | POLBCYP1A2USP2HSD17B10MAPK1 | |
| SCHEMBL19701977 | 0.81 | NOTUM (0.56) | CYP1A2USP2HSD17B10MAPK1ALDH1A1 | |
| SCHEMBL23544867 | 0.80 | MAPT (0.50) | MAPK1ALDH1A1MAPTTSHRNOTUM | |
| SCHEMBL25839515 | 0.80 | ALDH1A1 (0.58) | POLBCYP1A2MAPK1CYP2C19ALDH1A1 | |
| SCHEMBL19701982 | 0.80 | NOTUM (0.54) | MAPK1ALDH1A1MAPTTSHRNOTUM | |
| SCHEMBL3689492 | 0.80 | POLB (0.63) | POLBCYP1A2USP2HSD17B10MAPK1 | |
| SCHEMBL23544851 | 0.79 | NOTUM (0.53) | MAPK1ALDH1A1MAPTTSHRNOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11697648-B2 | Fused pyrimidine pyridinone compounds as JAK inhibitors | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2023-07-11 | — | — | US | disclosed |
| US-11697648-B2 | Fused pyrimidine pyridinone compounds as JAK inhibitors | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2023-07-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11697648-B2 | Fused pyrimidine pyridinone compounds as JAK inhibitors | JAK3, JAK1, JAK2 | POLB 2819/4885CYP1A2 2216/4885USP2 3868/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.