Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.54 |
| ▸ | NPC1 | O15118 | 6/20 | 0.54 |
| ▸ | RAB9A | P51151 | 6/20 | 0.54 |
| ▸ | HPGD | P15428 | 5/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.54 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.53 |
| ▸ | CDK2 | P24941 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | CASP1 | P29466 | 1/20 | 0.50 |
| ▸ | CASP7 | P55210 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.48 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.48 |
| ▸ | RELA | Q04206 | 2/20 | 0.48 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.46 |
| ▸ | APAF1 | O14727 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28994151 | 0.88 | HSD17B10 (0.38) | ALDH1A1SMN1; SMN2KDM4ENPC1RAB9A | |
| SCHEMBL25839666 | 0.85 | CCNA2 (0.49) | ALDH1A1SMN1; SMN2KDM4ENPC1RAB9A | |
| SCHEMBL25170456 | 0.85 | KDM4E (0.46) | ALDH1A1SMN1; SMN2KDM4ENPC1RAB9A | |
| SCHEMBL25117830 | 0.84 | ALDH1A1 (0.62) | ALDH1A1SMN1; SMN2KDM4ENPC1RAB9A | |
| SCHEMBL25117842 | 0.83 | MAPT (0.48) | ALDH1A1SMN1; SMN2KDM4ENPC1RAB9A | |
| SCHEMBL25117825 | 0.82 | ALDH1A1 (0.52) | ALDH1A1SMN1; SMN2KDM4ENPC1RAB9A | |
| SCHEMBL25117794 | 0.82 | ALDH1A1 (0.60) | ALDH1A1SMN1; SMN2KDM4ENPC1RAB9A | |
| SCHEMBL25839780 | 0.81 | MAPT (0.47) | ALDH1A1SMN1; SMN2KDM4ENPC1RAB9A | |
| SCHEMBL25117823 | 0.80 | ALDH1A1 (0.58) | ALDH1A1SMN1; SMN2KDM4ENPC1RAB9A | |
| SCHEMBL20678782 | 0.79 | KDM4E (0.54) | ALDH1A1SMN1; SMN2KDM4ENPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230219978-A1 | COMPOUND HAVING MACROCYCLIC STRUCTURE AND USE THEREOF | SCINNOHUB PHARMACEUTICAL CO., LTD (CN) | 2023-07-13 | — | — | US | disclosed |
| CN-116063324-A | Inhibitors of BTK and/or RET having macrocyclic structure | 赛诺哈勃药业（成都）有限公司 | 2023-05-05 | — | — | CN | disclosed |
| CN-116063325-A | Macrocyclic compounds with BTK modulating effect and uses thereof | 赛诺哈勃药业（成都）有限公司 | 2023-05-05 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230219978-A1 | COMPOUND HAVING MACROCYCLIC STRUCTURE AND USE THEREOF | BTK, SRC, YES1 | ALDH1A1 4689/4885SMN1; SMN2 1720/4885KDM4E 1626/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.