Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OGA | O60502 | 6/20 | 0.52 |
| ▸ | MAPT | P10636 | 6/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.48 |
| ▸ | NPC1 | O15118 | 4/20 | 0.48 |
| ▸ | RAB9A | P51151 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | HTT | P42858 | 3/20 | 0.48 |
| ▸ | TP53 | P04637 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 4/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20014199 | 0.88 | OGA (0.46) | OGAMAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL20014258 | 0.87 | MAPT (0.46) | OGAMAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL19996070 | 0.86 | HTR1A (0.49) | OGAMAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL20013913 | 0.85 | MAPT (0.52) | OGAMAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL20014260 | 0.84 | CCNC (0.50) | MAPTRAB9AALDH1A1HTTKDM4E | |
| SCHEMBL20014255 | 0.84 | MAPT (0.54) | OGAMAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL20014254 | 0.83 | MAPT (0.48) | OGAMAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL20013931 | 0.82 | MAPT (0.53) | OGAMAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL20014653 | 0.80 | MAPT (0.52) | OGAMAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL19996064 | 0.79 | MAPT (0.55) | MAPTSMN1; SMN2NPC1RAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4275759-A2 | QUINOLINE DERIVATIVES AS CHROMOBOX (CBX) PROTEIN INHIBITORS FOR TREATING CANCER | Dana-Farber Cancer Institute, Inc. (US) | 2023-11-15 | — | — | EP | disclosed |
| EP-3515449-B1 | QUINOLINE DERIVATIVES AS CHROMOBOX (CBX) PROTEIN INHIBITORS FOR TREATING CANCER | DANA FARBER CANCER INST INC (US) | 2023-07-12 | — | — | EP | disclosed |