Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | IDO1 | P14902 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | FHIT | P49789 | 1/20 | 0.38 |
| ▸ | GABRP | O00591 | 1/20 | 0.38 |
| ▸ | GABRD | O14764 | 1/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.38 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10370830 | 0.79 | KDM4E (0.55) | KDM4EALDH1A1L3MBTL1IDO1HPGD | |
| SCHEMBL3051645 | 0.76 | HSD17B10 (0.56) | KDM4EALDH1A1L3MBTL1IDO1HPGD | |
| SCHEMBL31523508 | 0.76 | KDM4E (0.67) | KDM4EALDH1A1L3MBTL1IDO1MAPT | |
| SCHEMBL25391244 | 0.74 | KDM4E (0.53) | KDM4EALDH1A1L3MBTL1IDO1HPGD | |
| SCHEMBL20639130 | 0.74 | KDM4E (0.50) | KDM4EALDH1A1L3MBTL1IDO1HPGD | |
| SCHEMBL31523595 | 0.74 | KDM4E (0.64) | KDM4EALDH1A1L3MBTL1IDO1MAPT | |
| SCHEMBL10568608 | 0.73 | KDM4E (0.49) | KDM4EALDH1A1L3MBTL1IDO1HPGD | |
| SCHEMBL5480400 | 0.73 | KDM4E (0.63) | KDM4EALDH1A1L3MBTL1IDO1HPGD | |
| SCHEMBL26685489 | 0.72 | ALDH1A1 (0.43) | KDM4EALDH1A1L3MBTL1HPGDMAPT | |
| SCHEMBL9592772 | 0.72 | KDM4E (0.40) | KDM4EALDH1A1L3MBTL1IDO1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023125877-A1 | TRICYCLIC DERIVATIVE INHIBITOR, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF | 上海翰森生物医药科技有限公司 | 2023-07-06 | — | — | WO | disclosed |
| WO-2023125877-A1 | TRICYCLIC DERIVATIVE INHIBITOR, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF | 上海翰森生物医药科技有限公司 | 2023-07-06 | — | — | WO | disclosed |