Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | MAOB | P27338 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | BACE1 | P56817 | 1/20 | 0.49 |
| ▸ | CA12 | O43570 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.48 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5149274 | 1.00 | MAPT (0.56) | MAPTSOS1CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL9978289 | 0.82 | MAPT (0.69) | MAPTSOS1MAOBLMNAALDH1A1 | |
| SCHEMBL14935499 | 0.82 | MAPT (0.69) | MAPTSOS1MAOBLMNAALDH1A1 | |
| SCHEMBL11049170 | 0.82 | MAPT (0.69) | MAPTSOS1MAOBLMNAALDH1A1 | |
| SCHEMBL4631530 | 0.82 | MAPT (0.60) | MAPTSOS1CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL9113908 | 0.82 | MAPT (0.56) | MAPTSOS1CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL10149216 | 0.82 | ALDH1A1 (0.57) | MAPTSOS1CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL7284481 | 0.82 | MAPT (0.56) | MAPTSOS1CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL4366480 | 0.82 | MAPT (0.56) | MAPTSOS1CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL4687052 | 0.82 | MAPT (0.56) | MAPTSOS1CYP1A2CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117624045-A | Compounds for the treatment of kinase dependent disorders | 埃克塞里艾克西斯公司 | 2024-03-01 | — | — | CN | disclosed |
| CN-106074591-A | RNA interference in eye disease | 雷克西制药公司 | 2016-11-09 | — | — | CN | disclosed |
| CN-105873910-A | Macrocyclic insulin-degrading enzyme (IDE) inhibitors and uses thereof | 哈佛大学的校长及成员们 | 2016-08-17 | — | — | CN | disclosed |
| CN-105705143-A | Nucleic acid nanostructures for in vivo agent delivery | 达娜-法勃肿瘤研究所公司 | 2016-06-22 | — | — | CN | disclosed |
| CN-105307667-A | Stapled and sutured polypeptides and uses thereof | HARVARD COLLEGE | 2016-02-03 | — | — | CN | disclosed |
| CN-103108642-B | RNA interference in cutaneous and fibrotic conditions | Lexie Pharmaceuticals (US) | 2015-09-23 | — | — | CN | disclosed |
| CN-102971288-B | Novel process for producing bisaminophenylalkylurea | NISSAN CHEMICAL IND LTD | 2015-01-21 | — | — | CN | disclosed |
| CN-102971288-A | Novel process for producing bisaminophenylalkylurea | NISSAN CHEMICAL IND LTD | 2013-03-13 | — | — | CN | disclosed |
| WO-2011136231-A1 | NOVEL PROCESS FOR PRODUCING BISAMINOPHENYLALKYLUREA | 日産化学工業株式会社 (JP) | 2011-11-03 | — | — | WO | disclosed |
| EP-1863483-A1 | BICYCLIC PYRAZOLE COMPOUNDS AS ANTIBACTERIAL AGENTS | Janssen Pharmaceutica, N.V. (BE) | 2007-12-12 | — | — | EP | disclosed |
| WO-2006105289-A1 | BICYCLIC PYRAZOLE COMPOUNDS AS ANTIBACTERIAL AGENTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-10-05 | — | — | WO | disclosed |
| EP-0394058-A1 | Alicyclic diamines, alicyclic diisocyanates and polyisocyanato-isocyanurates and method for the preparation thereof | MITSUI TOATSU CHEMICALS, Inc. (JP) | 1990-10-24 | — | — | EP | disclosed |