Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 13/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2590978 | 0.89 | GPR119 (0.35) | GPR119KDM4ELIPG | |
| SCHEMBL2590815 | 0.84 | GPR119 (0.38) | GPR119 | |
| SCHEMBL12178000 | 0.83 | GPR119 (0.52) | GPR119KDM4E | |
| SCHEMBL14729004 | 0.80 | GPR119 (0.54) | GPR119KDM4ENPC1RAB9A | |
| SCHEMBL2588641 | 0.80 | GPR119 (0.36) | GPR119LIPG | |
| SCHEMBL2589083 | 0.79 | GPR119 (0.38) | GPR119 | |
| SCHEMBL2592310 | 0.78 | GPR119 (0.40) | GPR119KDM4ENPC1RAB9A | |
| SCHEMBL2583933 | 0.78 | GPR119 (0.37) | GPR119LIPG | |
| SCHEMBL2588548 | 0.78 | GPR119 (0.49) | GPR119KDM4ENPC1RAB9A | |
| SCHEMBL14759037 | 0.78 | GPR119 (0.36) | GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2566860-A1 | BICYCLIC HETEROARYL COMPOUNDS AS GPR119 MODULATORS | Bristol-Myers Squibb Company (US) | 2013-03-13 | — | — | EP | disclosed |
| WO-2011140160-A1 | BICYCLIC HETEROARYL COMPOUNDS AS GPR119 MODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2011-11-10 | — | — | WO | disclosed |