Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 8/20 | 0.45 |
| ▸ | NR1H4 | Q96RI1 | 4/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.38 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | PPARD | Q03181 | 1/20 | 0.35 |
| ▸ | PPARA | Q07869 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25848967 | 0.93 | TRPV1 (0.45) | EPHX2NR1H4HDAC1HDAC6TRPV1 | |
| SCHEMBL25848856 | 0.91 | EPHX2 (0.43) | EPHX2NR1H4HDAC1HDAC6DDR1 | |
| SCHEMBL25848848 | 0.89 | EPHX2 (0.48) | EPHX2NR1H4HDAC1HDAC6TRPV1 | |
| SCHEMBL25848773 | 0.85 | P2RX7 (0.41) | EPHX2NR1H4HDAC1HDAC6KMT2A | |
| SCHEMBL25848887 | 0.84 | EPHX2 (0.45) | EPHX2NR1H4HDAC1HDAC6DDR1 | |
| SCHEMBL24196659 | 0.83 | MCL1 (0.42) | EPHX2NR1H4HDAC1HDAC6DDR1 | |
| SCHEMBL25848961 | 0.82 | TRPV1 (0.48) | EPHX2NR1H4HDAC1HDAC6TRPV1 | |
| SCHEMBL25848857 | 0.80 | EPHX2 (0.45) | EPHX2NR1H4HDAC1HDAC6DDR1 | |
| SCHEMBL25848776 | 0.79 | EPHX2 (0.42) | EPHX2HDAC1HDAC6DDR1HDAC4 | |
| SCHEMBL25849324 | 0.78 | PPARA (0.49) | EPHX2HDAC1HDAC6HDAC4HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230219921-A1 | KCNT1 INHIBITORS AND METHODS OF USE | PRAXIS PRECISION MEDICINES, INC. | 2023-07-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230219921-A1 | KCNT1 INHIBITORS AND METHODS OF USE | KCNT1, KCNT2, KCNQ2 | EPHX2 2590/4885NR1H4 3085/4885HDAC1 1680/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.