SCHEMBL25849744

SCHEMBL25849744

CN1c2ccc(-c3ccccc3)cc2C(C)(C)c2c1ccc1cc(C=C3C(=O)c4cc5ccccc5cc4C3=O)ccc21

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
BCL2 P10415 2/20 0.36
BAX Q07812 2/20 0.36
BCL2L1 Q07817 2/20 0.36
MAPT P10636 5/20 0.34
KDM4E B2RXH2 1/20 0.34
ALDH1A1 P00352 1/20 0.34
GAA P10253 1/20 0.34
KMT2A Q03164 3/20 0.31
MEN1 O00255 2/20 0.31
HPGD P15428 1/20 0.31
CDC25A P30304 1/20 0.31
CDC25B P30305 1/20 0.31
CTDSP1 Q9GZU7 1/20 0.31
TDP1 Q9NUW8 1/20 0.31
L3MBTL1 Q9Y468 1/20 0.31
BRD4 O60885 1/20 0.31
RET P07949 1/20 0.31
CREBBP Q92793 1/20 0.31
LCK P06239 1/20 0.31
USP2 O75604 2/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25849752 0.90 BCL2 (0.33) BCL2BAXBCL2L1MAPTKDM4E
SCHEMBL25849707 0.89 MAPT (0.39) MAPTKDM4EALDH1A1GAAKMT2A
SCHEMBL25849748 0.89 BCL2 (0.33) BCL2BAXBCL2L1MAPTKDM4E
SCHEMBL25849761 0.89 KDM4E (0.34) BCL2BAXBCL2L1MAPTKDM4E
SCHEMBL22177616 0.89 BCL2 (0.36) BCL2BAXBCL2L1MAPTKDM4E
SCHEMBL18267287 0.89 BCL2 (0.35) BCL2BAXBCL2L1MAPTKDM4E
SCHEMBL25849766 0.89 KMT2A (0.37) BCL2BAXBCL2L1MAPTKDM4E
SCHEMBL25849757 0.88 KDM4E (0.33) BCL2BAXBCL2L1MAPTKDM4E
SCHEMBL25849769 0.86 CSNK2A2 (0.39) BCL2BAXBCL2L1MAPTKDM4E
SCHEMBL17426014 0.85 PDE6D (0.34) BCL2BAXBCL2L1MAPTKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230232713-A1 PHOTOELECTRIC CONVERSION ELEMENT, IMAGING ELEMENT, OPTICAL SENSOR, AND COMPOUND FUJIFILM CORPORATION (JP) 2023-07-20 US disclosed