Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.34 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | TOP1 | P11387 | 2/20 | 0.34 |
| ▸ | HRAS | P01112 | 1/20 | 0.34 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | USP4 | Q13107 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19636936 | 0.80 | ERBB2 (0.40) | POLBERBB2LMNATOP1HRAS | |
| SCHEMBL19633220 | 0.79 | ERBB2 (0.40) | POLBERBB2LMNATOP1HRAS | |
| SCHEMBL19633222 | 0.79 | USP4 (0.39) | POLBKDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL19633223 | 0.77 | NAMPT (0.43) | TOP1HRASESR1ESR2KDM4E | |
| SCHEMBL19636934 | 0.73 | ERBB2 (0.41) | ERBB2MAPTALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL19636845 | 0.72 | ERBB2 (0.40) | ERBB2KDM4EMAPT | |
| Hydrochloric Acid SCHEMBL30944564 | 0.71 | MEN1 (0.41) | POLBLMNATOP1HRASESR1 | |
| SCHEMBL30944502 | 0.70 | NAMPT (0.42) | POLBTOP1HRASESR1ESR2 | |
| SCHEMBL30944532 | 0.70 | NAMPT (0.42) | POLBTOP1HRASESR1ESR2 | |
| SCHEMBL25855374 | 0.70 | ERBB2 (0.38) | ERBB2KDM4EMAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3458069-B1 | PYRROLOBENZODIAZEPINES AND CONJUGATES THEREOF | MERSANA THERAPEUTICS INC (US) | 2023-07-05 | — | — | EP | disclosed |