USP4 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL13024499	1.00	1/20
Vialinin A (SCHEMBL29559604)	1.00	1/20
SCHEMBL13065926	0.84	1/20
SCHEMBL18079755	0.84	1/20
SCHEMBL13985248	0.74	1/20
SCHEMBL27306270	0.72	1/20
Vialinin B (SCHEMBL29711168)	0.63	1/20
SCHEMBL417740	0.62	1/20
SCHEMBL29190969	0.61	1/20
SCHEMBL10412909	0.60	1/20
SCHEMBL417739	0.58	1/20
SCHEMBL29711334	0.58	1/20
SCHEMBL11173991	0.56	1/20
SCHEMBL57331	0.54	1/20
SCHEMBL2637879	0.54	1/20
SCHEMBL6937307	0.54	1/20
SCHEMBL8483573	0.54	1/20
SCHEMBL9387702	0.53	1/20
SCHEMBL29711304	0.53	1/20
SCHEMBL31438443	0.53	1/20

Clinical trials — most relevant to USP4 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Hypoxia-inducible Factor Prolyl Hydroxylase Inhibitors on Sarcopenia in Hemodialysis Patients	PHASE4	NOT_YET_RECRUITING
Relapsed and/or Refractory Non-Hodgkin Lymphoma Study	PHASE2	WITHDRAWN
Alrizomadlin (APG-115) in Subjects With BAP1 Cancer Syndrome and Early-Stage Mesothelioma	PHASE2	WITHDRAWN
Desferal Administration to Improve the Impaired Reaction to Hypoxia in Diabetes	PHASE2	UNKNOWN
Effect of Deferoxamine on Wound Healing Rate in Patients With Diabetes Foot Ulcers	PHASE2	NOT_YET_RECRUITING
Decitabine/Cedazuridine (INQOVI), an Oral DNA Demethylating Agent, in Subjects With BAP1 Cancer Predisposition Syndrome and Subclinical, Early-Stage Mesothelioma	PHASE2	SUSPENDED
The Effect of Roxadustat on Renal Oxygenation in Diabetes Nephropathy	PHASE2	NOT_YET_RECRUITING
Phase II Study of Vandetanib in Individuals With Kidney Cancer	PHASE2	COMPLETED
PS-341 and Radiation to Treat Advanced Cancer of the Head and Neck	PHASE1	COMPLETED
Differential Gene Expression of Liver Tissue and Blood From Individuals With Chronic Viral Hepatitis	nan	UNKNOWN
Clinical Trial of Levodopa/Carbidopa ( Sinemet) Therapy in Angel Man Syndrome	nan	COMPLETED
Diagnostic Potential of UCHL1 in Acute Decompensated Heart Failure	nan	COMPLETED
Biomarkers in Tumor Samples From Younger Patients With Neuroblastoma	nan	COMPLETED
Frequency and Clinical Phenotype of BAP1 Hereditary Predisposition Syndrome	nan	RECRUITING
A Natural History Study of Angelman Syndrome	nan	RECRUITING
Long Term Follow-Up of Patients With Mesothelioma and Individuals With Germline Mutations in BAP1	nan	RECRUITING
Exercise Therapy to Reduce Heart Failure Symptoms; Sorting Mechanisms of Benefit	nan	COMPLETED
Effect of Dietary Nitrate on Immobilization-induced Changes in Skeletal Muscle in Young Healthy Men	nan	RECRUITING
The Role of RING Ubiquitin Ligases in Biologic and Oncologic Processes in Tissues of Mesenchymal Origin	nan	UNKNOWN
Prognostic Biomarkers in Tumor Tissue Samples From Young Patients With Neuroblastoma	nan	COMPLETED
Relationship Between Nutritional State and Respiratory Muscle Weakness in Adult Patients With Bronchietasis	nan	UNKNOWN
Quantification of GADD34 Expression in RA	nan	COMPLETED
Identification of a New Blood Biomarker for the Diagnosis and Prognosis of Liposarcomas	nan	RECRUITING
Inhibition of SENP1 for the Suppression of OS Growth and Metastasis	nan	UNKNOWN
Low Dose Melphalan and Bortezomib for AML and High-Risk MDS	nan	COMPLETED
Evaluation of Proteasome as a Marker of Hepatocellular Carcinoma in Cirrhotic Patients Following Curative Treatment	nan	UNKNOWN
Transcutaneous Electrical Diaphragmatic Stimulation in Critically Ill Elderly Patients	nan	UNKNOWN
Prospective Evaluation of High Resolution Dual Energy Computed Tomographic Imaging, Noninvasive (Liquid) Biopsies, and Minimally Invasive Surgical Surveillance for Early Detection of Mesotheliomas in Patients With BAP1 Tumor Predisposition Syndrome	nan	RECRUITING
Long Term Prediction of MASH-related HCC Risk by Proteomics	nan	NOT_YET_RECRUITING
Clinical Study of 68Ga-DOTA-BLP PET Imaging in Noninvasive Diagnosis of Malignant Tumors	nan	NOT_YET_RECRUITING

Related proteins — ESM-2 sequence neighbours (a USP4 binder may also engage these)

Protein	Name	Similarity
Q5RCD3	—	1.000	Q5RCD3 →
A6QR55	—	1.000	A6QR55 →
P35123	—	1.000	P35123 →
B2GUZ1	—	1.000	B2GUZ1 →
Q2HJE4	—	1.000	Q2HJE4 →
Q93Y01	—	1.000	Q93Y01 →
F6Z5C0	—	1.000	F6Z5C0 →
Q8R5H1	—	1.000	Q8R5H1 →
Q9R085	—	1.000	Q9R085 →
Q5D006	—	1.000	Q5D006 →
P51784	—	0.999	P51784 →
Q99K46	—	0.999	Q99K46 →
O22207	—	0.997	O22207 →
Q9MAQ3	—	0.997	Q9MAQ3 →
Q9Y4E8	—	0.996	Q9Y4E8 →
NFKB1	Nuclear factor NF-kappa-B p105 subunit	0.994	landscape →
P25799	—	0.993	P25799 →
F8VPZ3	—	0.993	F8VPZ3 →
Q09879	—	0.993	Q09879 →
Q9ZSB5	—	0.993	Q9ZSB5 →
Q9USM5	—	0.993	Q9USM5 →
Q12756	—	0.992	Q12756 →
Q01988	—	0.991	Q01988 →
P70600	—	0.991	P70600 →
Q8BX57	—	0.991	Q8BX57 →
Q8BWR4	—	0.991	Q8BWR4 →
INPP5B	Type II inositol 1,4,5-trisphosphate 5-phosphatase	0.991	landscape →
KDM5D	Lysine-specific demethylase 5D	0.990	landscape →
DCLK1	Serine/threonine-protein kinase DCLK1	0.990	landscape →
Q9H1H9	—	0.990	Q9H1H9 →