Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Jnj-42396302. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 6/20 | 0.91 |
| ▸ | PDE2A | O00408 | 1/20 | 0.91 |
| ▸ | PDE8A | O60658 | 1/20 | 0.91 |
| ▸ | PDE5A | O76074 | 1/20 | 0.91 |
| ▸ | PDE9A | O76083 | 1/20 | 0.91 |
| ▸ | PDE6A | P16499 | 1/20 | 0.91 |
| ▸ | HTR2C | P28335 | 1/20 | 0.91 |
| ▸ | HTR7 | P34969 | 1/20 | 0.91 |
| ▸ | HTR2B | P41595 | 1/20 | 0.91 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.91 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.91 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.91 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.91 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.91 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Jnj-42396302 SCHEMBL1824885 | 0.95 | PDE10A (1.00) | PDE10APDE2APDE8APDE5APDE9A | |
| Jnj-42396302 SCHEMBL1827550 | 0.95 | PDE10A (0.98) | PDE10APDE2APDE8APDE5APDE9A | |
| Jnj-42396302 SCHEMBL2586336 | 0.95 | PDE10A (0.98) | PDE10APDE2APDE8APDE5APDE9A | |
| Jnj-42396302 SCHEMBL1824260 | 0.92 | PDE10A (0.85) | PDE10APDE2APDE8APDE5APDE9A | |
| Jnj-42396302 SCHEMBL1824259 | 0.92 | PDE10A (0.85) | PDE10APDE2APDE8APDE5APDE9A | |
| SCHEMBL1828319 | 0.90 | PDE10A (0.89) | PDE10APDE2APDE8APDE5APDE9A | |
| SCHEMBL1821902 | 0.86 | PDE10A (0.83) | PDE10APDE2APDE8APDE5APDE9A | |
| SCHEMBL1825516 | 0.86 | PDE10A (0.81) | PDE10APDE2APDE8APDE5APDE9A | |
| SCHEMBL1824412 | 0.85 | PDE10A (0.81) | PDE10APDE2APDE8APDE5APDE9A | |
| SCHEMBL1824053 | 0.83 | PDE10A (0.78) | PDE10APDE2APDE8APDE5APDE9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8716282-B2 | Imidazo[1,2-b]pyridazine derivatives and their use as PDE10 inhibitors | JANSSEN PHARMACEUTICA NV (BE) | 2014-05-06 | — | — | US | claimed |
| US-20110269752-A1 | IMIDAZO[1,2-b]PYRIDAZINE DERIVATIVES AND THEIR USE AS PDE10 INHIBITORS | PASTOR-FERNANDEZ JOAQUIN | 2011-11-03 | — | — | US | claimed |
| EP-2702062-B1 | SALT OF AN INHIBITOR OF PHOSPHODIESTERASE 10 ENZYME | JANSSEN PHARMACEUTICA NV (BE) | 2015-12-16 | — | — | EP | disclosed |
| US-8716282-B2 | Imidazo[1,2-b]pyridazine derivatives and their use as PDE10 inhibitors | JANSSEN PHARMACEUTICA NV (BE) | 2014-05-06 | — | — | US | disclosed |
| EP-2702062-A1 | SALT OF AN INHIBITOR OF PHOSPHODIESTERASE 10 ENZYME | Janssen Pharmaceutica, N.V. (BE) | 2014-03-05 | — | — | EP | disclosed |
| WO-2012146644-A1 | SALT OF AN INHIBITOR OF PHOSPHODIESTERASE 10 ENZYME | JANSSEN PHARMACEUTICA NV (BE) | 2012-11-01 | — | — | WO | disclosed |
| US-20110269752-A1 | IMIDAZO[1,2-b]PYRIDAZINE DERIVATIVES AND THEIR USE AS PDE10 INHIBITORS | PASTOR-FERNANDEZ JOAQUIN | 2011-11-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110269752-A1 | IMIDAZO[1,2-b]PYRIDAZINE DERIVATIVES AND THEIR USE AS PDE10 INHIBITORS | PDE12, PDE10A, PDE5A | PDE10A 2/4885PDE2A 4/4885PDE8A 19/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.