Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NLRP3 | Q96P20 | 7/20 | 0.62 |
| ▸ | IL1B | P01584 | 6/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | TNF | P01375 | 1/20 | 0.46 |
| ▸ | IDH2 | P48735 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | TLR2 | O60603 | 4/20 | 0.36 |
| ▸ | TLR1 | Q15399 | 4/20 | 0.36 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.36 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29326352 | 0.84 | NLRP3 (0.62) | NLRP3IL1BKCNH2TNFIDH2 | |
| SCHEMBL29326657 | 0.84 | NLRP3 (0.60) | NLRP3IL1BKCNH2TNFIDH2 | |
| SCHEMBL26439328 | 0.83 | NLRP3 (0.53) | NLRP3IL1BKCNH2TNFKDM4E | |
| SCHEMBL29326652 | 0.83 | NLRP3 (0.56) | NLRP3IL1BKCNH2TNFIDH2 | |
| SCHEMBL29326464 | 0.83 | NLRP3 (0.56) | NLRP3IL1BKCNH2TNFSORT1 | |
| SCHEMBL31314222 | 0.82 | NLRP3 (0.53) | NLRP3IL1BKCNH2TNFTLR2 | |
| SCHEMBL29326394 | 0.82 | NLRP3 (0.58) | NLRP3IL1BKCNH2TNFIDH2 | |
| SCHEMBL29326589 | 0.82 | NLRP3 (0.58) | NLRP3IL1BKCNH2TNFIDH2 | |
| SCHEMBL29326837 | 0.82 | NLRP3 (0.60) | NLRP3IL1BKCNH2TNFIDH2 | |
| SCHEMBL29326349 | 0.82 | NLRP3 (0.55) | NLRP3IL1BKCNH2TNFKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023131277-A1 | NLRP3 INFLAMMASOME INHIBITOR AND USES THEREOF | 药捷安康(南京)科技股份有限公司 | 2023-07-13 | — | — | WO | disclosed |