Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 1/20 | 0.31 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.31 |
| ▸ | RET | P07949 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25859958 | 0.94 | ABCB1 (0.32) | ABCB1GPR119RET | |
| SCHEMBL25859997 | 0.87 | ABCB1 (0.31) | ABCB1GPR119 | |
| SCHEMBL25622781 | 0.85 | PIK3R1 (0.31) | ABCB1GPR119RET | |
| SCHEMBL25622674 | 0.84 | ABCB1 (0.33) | ABCB1GPR119RET | |
| SCHEMBL25860001 | 0.83 | GPR119 (0.31) | GPR119 | |
| SCHEMBL25859956 | 0.81 | GPR119 (0.37) | ABCB1GPR119 | |
| SCHEMBL25864700 | 0.81 | GPR119 (0.37) | ABCB1GPR119 | |
| SCHEMBL25621191 | 0.81 | GPR119 (0.37) | ABCB1GPR119RET | |
| SCHEMBL25620238 | 0.80 | JAK3 (0.37) | ABCB1GPR119RET | |
| SCHEMBL25864346 | 0.80 | JAK3 (0.37) | ABCB1GPR119RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230227470-A1 | ANNULATED 2-AMINO-3-CYANO THIOPHENES AND DERIVATIVES FOR THE TREATMENT OF CANCER | VANDERBILT UNIVERSITY | 2023-07-20 | — | — | US | disclosed |
| US-20230227470-A1 | ANNULATED 2-AMINO-3-CYANO THIOPHENES AND DERIVATIVES FOR THE TREATMENT OF CANCER | VANDERBILT UNIVERSITY | 2023-07-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230227470-A1 | ANNULATED 2-AMINO-3-CYANO THIOPHENES AND DERIVATIVES FOR THE TREATMENT OF CANCER | KRAS, NRAS, TP53 | ABCB1 127/4885GPR119 1460/4885RET 36/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.