Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AVPR2 | P30518 | 10/20 | 0.55 |
| ▸ | OXTR | P30559 | 3/20 | 0.55 |
| ▸ | AVPR1A | P37288 | 12/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2586409 | 1.00 | AVPR2 (0.55) | AVPR2OXTRAVPR1AKCNH2 | |
| SCHEMBL2587654 | 0.89 | AVPR1A (0.55) | AVPR2OXTRAVPR1AKCNH2 | |
| SCHEMBL2587656 | 0.89 | AVPR1A (0.55) | AVPR2OXTRAVPR1AKCNH2 | |
| SCHEMBL2589870 | 0.89 | AVPR1A (0.55) | AVPR2OXTRAVPR1AKCNH2 | |
| SCHEMBL2579256 | 0.87 | AVPR1A (0.68) | AVPR2OXTRAVPR1AKCNH2 | |
| SCHEMBL2579259 | 0.87 | AVPR1A (0.68) | AVPR2OXTRAVPR1AKCNH2 | |
| SCHEMBL2583730 | 0.85 | AVPR1A (0.69) | AVPR2AVPR1AKCNH2 | |
| SCHEMBL2586453 | 0.85 | AVPR1A (0.69) | AVPR2AVPR1AKCNH2 | |
| SCHEMBL2583728 | 0.85 | AVPR1A (0.69) | AVPR2AVPR1AKCNH2 | |
| SCHEMBL2587646 | 0.84 | AVPR1A (0.54) | AVPR2OXTRAVPR1AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2569319-B1 | HETEROARYL-CYCLOHEXYL-TETRAAZABENZO[E]AZULENES | HOFFMANN LA ROCHE (CH) | 2014-09-24 | — | — | EP | claimed |
| US-8513238-B2 | Heteroaryl-cyclohexyl-tetraazabenzo[E]azulenes | HOFFMANN-LA ROCHE INC. (US) | 2013-08-20 | — | — | US | claimed |
| US-20110275801-A1 | HETEROARYL-CYCLOHEXYL-TETRAAZABENZO[E]AZULENES | HOFFMANN-LA ROCHE, INC. | 2011-11-10 | — | — | US | claimed |
| EP-2569319-B1 | HETEROARYL-CYCLOHEXYL-TETRAAZABENZO[E]AZULENES | HOFFMANN LA ROCHE (CH) | 2014-09-24 | — | — | EP | disclosed |
| US-8513238-B2 | Heteroaryl-cyclohexyl-tetraazabenzo[E]azulenes | HOFFMANN-LA ROCHE INC. (US) | 2013-08-20 | — | — | US | disclosed |
| US-20110275801-A1 | HETEROARYL-CYCLOHEXYL-TETRAAZABENZO[E]AZULENES | HOFFMANN-LA ROCHE, INC. | 2011-11-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110275801-A1 | HETEROARYL-CYCLOHEXYL-TETRAAZABENZO[E]AZULENES | AVPR1A, AVPR1B, OXTR | AVPR2 4/4885OXTR 3/4885AVPR1A 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.