SCHEMBL25865613

SCHEMBL25865613

Cn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)[C@@H]4COCC[C@@H]4N)cc3)cc21

nearest known ligand 0.64

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CTSC P53634 20/20 0.64
KCNH2 Q12809 2/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL289755 0.87 CTSC (0.69) CTSCKCNH2
SCHEMBL30738874 0.85 CTSC (0.71) CTSCKCNH2
SCHEMBL30738931 0.83 CTSC (0.68) CTSCKCNH2
SCHEMBL27380951 0.83 CTSC (0.68) CTSCKCNH2
SCHEMBL27381155 0.82 CTSC (0.73) CTSCKCNH2
SCHEMBL32680926 0.82 CTSC (0.73) CTSCKCNH2
SCHEMBL30738859 0.82 CTSC (0.73) CTSCKCNH2
SCHEMBL27381624 0.82 CTSC (0.73) CTSCKCNH2
SCHEMBL27380953 0.82 CTSC (0.73) CTSCKCNH2
SCHEMBL29294889 0.81 CTSC (0.68) CTSCKCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023134656-A1 PEPTIDYL NITRILE COMPOUND AND USE THEREOF 上海壹典医药科技开发有限公司 2023-07-20 WO disclosed