SCHEMBL2586782

SCHEMBL2586782

CC(C(N)=O)(c1ccc(-c2noc(-c3cnn(-c4ccccc4)c3C(F)(F)F)n2)cc1)C1(O)CCCCC1

nearest known ligand 0.54

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
S1PR1 P21453 5/20 0.54
POLB P06746 3/20 0.39
MAPT P10636 3/20 0.38
SMN1; SMN2 Q16637 2/20 0.38
KDM4E B2RXH2 2/20 0.38
MEN1 O00255 1/20 0.38
KMT2A Q03164 1/20 0.38
CHUK O15111 1/20 0.38
TXNRD1 Q16881 1/20 0.38
NOX4 Q9NPH5 1/20 0.38
LMNA P02545 1/20 0.38
HPGD P15428 1/20 0.36
NPC1 O15118 2/20 0.36
RAB9A P51151 2/20 0.36
ALDH1A1 P00352 1/20 0.36
TDP1 Q9NUW8 1/20 0.35
HDAC4 P56524 1/20 0.35
STAT3 P40763 1/20 0.34
NPSR1 Q6W5P4 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2591289 0.80 S1PR1 (0.63) S1PR1POLBMAPTSMN1; SMN2KDM4E
SCHEMBL27903357 0.79 S1PR1 (0.59) S1PR1POLBMAPTSMN1; SMN2KDM4E
SCHEMBL2591285 0.78 S1PR1 (0.58) S1PR1POLBMAPTSMN1; SMN2KDM4E
SCHEMBL2586781 0.77 S1PR1 (0.56) S1PR1POLBMAPTSMN1; SMN2CHUK
SCHEMBL14696504 0.77 S1PR1 (0.63) S1PR1POLBMAPTSMN1; SMN2KDM4E
SCHEMBL27903358 0.76 S1PR1 (0.64) S1PR1POLBMAPTSMN1; SMN2KDM4E
SCHEMBL27921152 0.74 S1PR1 (0.77) S1PR1POLBMAPTSMN1; SMN2KDM4E
SCHEMBL2579544 0.74 S1PR1 (0.77) S1PR1POLBMAPTSMN1; SMN2KDM4E
SCHEMBL27837557 0.73 S1PR1 (0.61) S1PR1MAPTSMN1; SMN2KDM4EMEN1
SCHEMBL1336500 0.73 S1PR1 (0.61) S1PR1POLBMAPTSMN1; SMN2KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2560969-A1 4 - (5 - ISOXAZOLYL OR 5 - PYRRAZOLYL -1,2,4- OXADIAZOL - 3 - YL) -MANDELIC ACID AMIDES AS SPHINGOSIN- 1 - PHOSPHATE 1 RRECEPTOR AGONISTS Bristol-Myers Squibb Company (US) 2013-02-27 EP disclosed
WO-2011133734-A1 4 - (5 - ISOXAZOLYL OR 5 - PYRRAZOLYL -1,2,4- OXADIAZOL - 3 - YL) -MANDELIC ACID AMIDES AS SPHINGOSIN- 1 - PHOSPHATE 1 RRECEPTOR AGONISTS BRISTOL-MYERS SQUIBB COMPANY (US) 2011-10-27 WO disclosed