Ammonia Solution, Strong

Ammonia Solution, Strong

SCHEMBL2586848

N.N.O=C(O)CC(O)C(=O)OC(CC(=O)O)C(=O)O

nearest known ligand 0.50

Full drug profile on Sugi Atlas →

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 1/20 0.50
TDP1 Q9NUW8 1/20 0.41
SLC22A6 Q4U2R8 1/20 0.37
TET2 Q6N021 6/20 0.32
GABRR1 P24046 2/20 0.32
KDM4A O75164 2/20 0.32
KDM4C Q9H3R0 2/20 0.32
KDM2A Q9Y2K7 2/20 0.32
TET3 O43151 2/20 0.32
LMNA P02545 1/20 0.32
OR51E2 Q9H255 1/20 0.31
PRSS1 P07477 1/20 0.30
TMPRSS15 P98073 1/20 0.30
TET1 Q8NFU7 1/20 0.30
FOLH1 Q04609 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1179759 0.98 SMN1; SMN2 (0.52) SMN1; SMN2TDP1SLC22A6TET2GABRR1
SCHEMBL24430 0.98 SMN1; SMN2 (0.52) SMN1; SMN2TDP1SLC22A6TET2GABRR1
Malic Acid SCHEMBL14125843 0.94 SMN1; SMN2 (0.60) SMN1; SMN2TDP1SLC22A6TET2GABRR1
SCHEMBL27705704 0.88 SMN1; SMN2 (0.41) SMN1; SMN2TDP1SLC22A6TET2GABRR1
SCHEMBL29144651 0.88 SMN1; SMN2 (0.41) SMN1; SMN2TDP1SLC22A6TET2GABRR1
SCHEMBL25255556 0.79 SMN1; SMN2 (0.39) SMN1; SMN2TDP1SLC22A6GABRR1LMNA
SCHEMBL726981 0.79 TP53 (0.40) SMN1; SMN2TDP1SLC22A6PRSS1TMPRSS15
SCHEMBL3386666 0.79 TSHR (0.42) SMN1; SMN2TDP1SLC22A6GABRR1LMNA
SCHEMBL157637 0.78 SMN1; SMN2 (0.54) SMN1; SMN2TDP1SLC22A6TET2GABRR1
SCHEMBL2180353 0.78 TP53 (0.39) SMN1; SMN2TDP1SLC22A6PRSS1TMPRSS15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20130184492-A1 PROCESSES FOR PRODUCING HOOC-R-COOH COMPOUND ACIDS FROM FERMENTATION BROTHS CONTAINING NH4+ -OOC-R-COO-NH4+ COMPOUNDS HERCULES TECHNOLOGY GROWTH CAPITAL, INC. 2013-07-18 US disclosed
EP-2571838-A1 PROCESSES FOR PRODUCING HOOC-R-COOH COMPOUND ACIDS FROM FERMENTATION BROTHS CONTAINING NH4+-OOC-R-COQ-NH4+ COMPOUNDS Bioamber, S.A.S. (FR) 2013-03-27 EP disclosed
WO-2011136945-A1 PROCESSES FOR PRODUCING HOOC-R-COOH COMPOUND ACIDS FROM FERMENTATION BROTHS CONTAINING NH4+ -OOC-R-COQ-NH4+ COMPOUNDS BIOAMBER S.A.S. (CA) 2011-11-03 WO disclosed