Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | POLA1 | P09884 | 1/20 | 0.31 |
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20032308 | 0.95 | TSHR (0.40) | TSHRRECQLPOLBPOLA1CA12 | |
| SCHEMBL24136313 | 0.89 | TSHR (0.37) | TSHRRECQLPOLBPOLA1CA12 | |
| SCHEMBL16185653 | 0.88 | GAA (0.37) | TSHRRECQLPOLBMEN1KMT2A | |
| SCHEMBL26700394 | 0.87 | TSHR (0.33) | TSHRRECQL | |
| SCHEMBL16902773 | 0.83 | HRH3 (0.42) | TSHRRECQLPOLBPOLA1ALDH1A1 | |
| SCHEMBL14190511 | 0.83 | HRH3 (0.39) | TSHRRECQLPOLBPOLA1CA12 | |
| SCHEMBL16185762 | 0.83 | GAA (0.40) | POLBALDH1A1KMT2A | |
| SCHEMBL26431008 | 0.80 | TSHR (0.35) | TSHRRECQLPOLBALDH1A1 | |
| SCHEMBL20429066 | 0.80 | TSHR (0.44) | TSHRRECQLPOLBPOLA1CA12 | |
| SCHEMBL445490 | 0.77 | TSHR (0.55) | TSHRRECQLPOLBPOLA1CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11767301-B2 | Bi-functional molecules to degrade circulating proteins | YALE UNIVERSITY (US) | 2023-09-26 | — | — | US | disclosed |
| US-20230271994-A1 | MOLECULAR DEGRADERS OF EXTRACELLULAR PROTEINS | UNIV YALE (US) | 2023-08-31 | — | — | US | disclosed |
| US-20230233689-A1 | Bifunctional Small Molecules to Target the Selective Degradation of Circulating Proteins | UNIV YALE (US) | 2023-07-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230271994-A1 | MOLECULAR DEGRADERS OF EXTRACELLULAR PROTEINS | ASGR1, MSR1, LDLR | TSHR 478/4885RECQL 3851/4885POLB 3511/4885 |
| US-11767301-B2 | Bi-functional molecules to degrade circulating proteins | MIF, ASGR1, FCGR2A | TSHR 943/4885RECQL 3219/4885POLB 4254/4885 |
| US-20230233689-A1 | Bifunctional Small Molecules to Target the Selective Degradation of Circulating Proteins | ASGR1, LDLR, FCGR2A | TSHR 665/4885RECQL 4311/4885POLB 4149/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.