Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 14/20 | 0.74 |
| ▸ | TNFSF11 | O14788 | 11/20 | 0.74 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.74 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30645540 | 0.85 | TNF (1.00) | TNFTNFSF11TNFRSF1A | |
| SCHEMBL1270919 | 0.85 | TNF (1.00) | TNFTNFSF11TNFRSF1A | |
| SCHEMBL29477172 | 0.85 | TNF (1.00) | TNFTNFSF11TNFRSF1A | |
| SCHEMBL25866714 | 0.85 | TNF (0.66) | TNFTNFSF11TNFRSF1A | |
| SCHEMBL15832294 | 0.80 | TNF (0.79) | TNFTNFSF11TNFRSF1A | |
| SCHEMBL15159836 | 0.79 | TNF (0.81) | TNFTNFSF11TNFRSF1A | |
| SCHEMBL15158389 | 0.78 | TNF (0.79) | TNFTNFSF11TNFRSF1A | |
| Hydrochloric Acid SCHEMBL4950341 | 0.78 | TNF (0.98) | TNFTNFSF11TNFRSF1A | |
| SCHEMBL15832298 | 0.78 | TNF (0.78) | TNFTNFSF11TNFRSF1A | |
| SCHEMBL20975834 | 0.77 | TNF (0.74) | TNFTNFSF11TNFRSF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230233689-A1 | Bifunctional Small Molecules to Target the Selective Degradation of Circulating Proteins | UNIV YALE (US) | 2023-07-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230233689-A1 | Bifunctional Small Molecules to Target the Selective Degradation of Circulating Proteins | ASGR1, LDLR, FCGR2A | TNF 2863/4885TNFSF11 121/4885TNFRSF1A 213/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.