Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.62 |
| ▸ | PKM | P14618 | 4/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7828814 | 0.77 | TSHR (1.00) | TSHRMAPK1PKMALDH1A1SMN1; SMN2 | |
| SCHEMBL2585688 | 0.74 | CD4 (0.49) | PKMALDH1A1POLBKMT2A | |
| SCHEMBL4264521 | 0.73 | TSHR (0.50) | TSHRMAPK1PKMALDH1A1SMN1; SMN2 | |
| SCHEMBL5243723 | 0.71 | TSHR (0.47) | TSHRMAPK1PKMALDH1A1SMN1; SMN2 | |
| SCHEMBL12656171 | 0.70 | PKM (0.77) | TSHRMAPK1PKMALDH1A1SMN1; SMN2 | |
| SCHEMBL2804968 | 0.69 | TSHR (0.54) | TSHRMAPK1PKMALDH1A1SMN1; SMN2 | |
| SCHEMBL12090158 | 0.69 | PKM (0.63) | TSHRMAPK1PKMALDH1A1SMN1; SMN2 | |
| SCHEMBL3282365 | 0.68 | TSHR (0.67) | TSHRMAPK1PKMALDH1A1SMN1; SMN2 | |
| SCHEMBL5415687 | 0.68 | PKM (0.85) | TSHRMAPK1PKMALDH1A1SMN1; SMN2 | |
| SCHEMBL5830802 | 0.68 | PKM (0.77) | TSHRMAPK1PKMALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8048879-B2 | Substituted 4,5,6,7-tetrahydro-isoxazolo[4,5-c]pyridine compounds and use thereof for producing medicaments | GRUENENTHAL GMBH (DE) | 2011-11-01 | — | — | US | disclosed |