Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | POLB | P06746 | 4/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.33 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.31 |
| ▸ | CASP3 | P42574 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.31 |
| ▸ | RELA | Q04206 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25311822 | 0.81 | MAPT (0.37) | MAPTLMNAPOLBHTTALDH1A1 | |
| SCHEMBL20094248 | 0.72 | PDE10A (0.41) | LMNASMN1; SMN2CYP1A2CYP2C19NPC1 | |
| SCHEMBL25311469 | 0.70 | ALDH1A1 (0.36) | MAPTLMNAHTTALDH1A1S1PR4 | |
| SCHEMBL25309468 | 0.68 | S1PR4 (0.39) | MAPTLMNAPOLBHTTALDH1A1 | |
| SCHEMBL25311595 | 0.67 | MAPT (0.38) | MAPTLMNAPOLBHTTALDH1A1 | |
| SCHEMBL25311294 | 0.67 | MAPT (0.35) | MAPTLMNAPOLBHTTALDH1A1 | |
| SCHEMBL25310974 | 0.65 | ALDH1A1 (0.36) | MAPTNPSR1LMNAPOLBHTT | |
| SCHEMBL25312423 | 0.65 | MAPT (0.36) | MAPTLMNAHTTALDH1A1SMN1; SMN2 | |
| SCHEMBL31393110 | 0.64 | KDM4E (0.45) | MAPTLMNAPOLBHTTALDH1A1 | |
| SCHEMBL31038494 | 0.64 | ALDH1A1 (0.39) | MAPTLMNAPOLBALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023139479-A1 | SUBSTITUTED BICYCLIC HETEROCYCLES AS MALT-1 INHIBITORS | AURIGENE ONCOLOGY LIMITED (IN) | 2023-07-27 | — | — | WO | disclosed |