Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.70 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.51 |
| ▸ | MMP8 | P22894 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MDM4 | O15151 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.41 |
| ▸ | GPR88 | Q9GZN0 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23542105 | 0.88 | KMT2A (0.60) | SMN1; SMN2SLC22A1KMT2AMEN1LMNA | |
| SCHEMBL21275416 | 0.85 | SMN1; SMN2 (0.84) | SMN1; SMN2SLC22A1MMP8KMT2AMEN1 | |
| SCHEMBL27574237 | 0.84 | SMN1; SMN2 (0.68) | SMN1; SMN2SLC22A1MMP8KMT2AMEN1 | |
| SCHEMBL21275440 | 0.84 | SMN1; SMN2 (0.68) | SMN1; SMN2SLC22A1MMP8KMT2AMEN1 | |
| SCHEMBL1632366 | 0.82 | SMN1; SMN2 (0.67) | SMN1; SMN2SLC22A1MMP8KMT2AMEN1 | |
| SCHEMBL14306758 | 0.82 | SMN1; SMN2 (0.75) | SMN1; SMN2SLC22A1MMP8KMT2AMEN1 | |
| SCHEMBL3005469 | 0.81 | SMN1; SMN2 (0.73) | SMN1; SMN2SLC22A1MMP8KMT2AMEN1 | |
| SCHEMBL4047441 | 0.81 | SMN1; SMN2 (0.60) | SMN1; SMN2MMP8KMT2AMEN1PIN1 | |
| SCHEMBL29057360 | 0.81 | SMN1; SMN2 (0.47) | SMN1; SMN2SLC22A1KMT2AMEN1KDM4E | |
| SCHEMBL27884383 | 0.81 | SMN1; SMN2 (0.47) | SMN1; SMN2SLC22A1KMT2AMEN1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023137634-A1 | TRICYCLIC COMPOUND, PREPARATION THEREFOR, PHARMACEUTICAL COMPOSITION AND USE | 上海奕拓医药科技有限责任公司 | 2023-07-27 | — | — | WO | disclosed |