Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
| ▸ | MMP8 | P22894 | 2/20 | 0.55 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | MDM4 | O15151 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8284231 | 0.84 | SMN1; SMN2 (0.61) | SMN1; SMN2MMP8PIN1KMT2AMEN1 | |
| SCHEMBL23593786 | 0.84 | KMT2A (0.60) | KMT2AMEN1LMNATSHR | |
| SCHEMBL27574237 | 0.83 | SMN1; SMN2 (0.68) | SMN1; SMN2MMP8PIN1KMT2AMEN1 | |
| SCHEMBL11841853 | 0.81 | SMN1; SMN2 (0.62) | SMN1; SMN2MMP8PIN1KMT2AMEN1 | |
| SCHEMBL16060720 | 0.81 | CTSL (0.50) | SMN1; SMN2KMT2AMEN1CA12CA1 | |
| SCHEMBL24661545 | 0.81 | SMN1; SMN2 (0.62) | SMN1; SMN2MMP8PIN1KMT2AMEN1 | |
| SCHEMBL3937562 | 0.81 | SMN1; SMN2 (0.58) | SMN1; SMN2MMP8PIN1KMT2AMEN1 | |
| SCHEMBL25870547 | 0.81 | SMN1; SMN2 (0.70) | SMN1; SMN2MMP8PIN1KMT2AMEN1 | |
| SCHEMBL28510565 | 0.80 | SMN1; SMN2 (0.61) | SMN1; SMN2MMP8PIN1KMT2AMEN1 | |
| SCHEMBL14401349 | 0.79 | SMN1; SMN2 (0.56) | SMN1; SMN2MMP8PIN1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1836173-A4 | ANTI-INFLAMMATORY MEDICAMENTS | DECIPHERA PHARMACEUTICALS LLC (US) | 2009-07-08 | — | — | EP | disclosed |
| EP-1836173-A2 | ANTI-INFLAMMATORY MEDICAMENTS | Deciphera Pharmaceuticals, LLC (US) | 2007-09-26 | — | — | EP | disclosed |
| WO-2006081034-A2 | ANTI-INFLAMMATORY MEDICAMENTS | DECIPHERA PHARMACEUTICALS, LLC (US) | 2006-08-03 | — | — | WO | disclosed |