Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 4/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.43 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27381769 | 0.87 | POLB (0.55) | POLBL3MBTL1NPSR1OPRM1OPRL1 | |
| SCHEMBL25091528 | 0.86 | POLB (0.44) | POLBL3MBTL1NPSR1OPRM1OPRL1 | |
| SCHEMBL25870353 | 0.85 | POLB (0.46) | POLBL3MBTL1NPSR1OPRM1OPRL1 | |
| SCHEMBL25876651 | 0.83 | POLB (0.49) | POLBL3MBTL1NPSR1OPRM1OPRL1 | |
| SCHEMBL15125407 | 0.82 | OPRM1 (0.57) | POLBL3MBTL1NPSR1OPRM1OPRL1 | |
| SCHEMBL23763285 | 0.80 | USP2 (0.44) | CYP3A4USP2ALDH1A1CYP2D6 | |
| SCHEMBL25870439 | 0.79 | POLB (0.47) | POLBL3MBTL1NPSR1OPRM1OPRL1 | |
| SCHEMBL23763284 | 0.79 | USP2 (0.42) | CYP3A4USP2ALDH1A1CYP2D6 | |
| SCHEMBL14297481 | 0.78 | POLB (0.53) | POLBL3MBTL1NPSR1ALDH1A1KMT2A | |
| SCHEMBL12764374 | 0.78 | POLB (0.53) | POLBL3MBTL1NPSR1CYP3A4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023116920-A1 | PENTA- FUSED HEXA-HETEROCYCLIC COMPOUND, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USE | 杭州多域生物技术有限公司 | 2023-06-29 | — | — | WO | disclosed |