SCHEMBL25875866

SCHEMBL25875866

COc1cc2c(O)cc3c(c2cc1N1CCCCC1)-c1ccccc1C3(CCC(F)(F)F)CCC(F)(F)F

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTPN1 P18031 2/20 0.35
ALDH1A1 P00352 4/20 0.34
HPGD P15428 2/20 0.34
PDK2 Q15119 4/20 0.34
DRD2 P14416 1/20 0.33
DRD4 P21917 1/20 0.33
HRH2 P25021 1/20 0.33
HRH1 P35367 1/20 0.33
DRD3 P35462 1/20 0.33
MAPT P10636 4/20 0.33
L3MBTL1 Q9Y468 2/20 0.33
KDM4E B2RXH2 1/20 0.33
MAOB P27338 1/20 0.33
ACHE P22303 2/20 0.32
S1PR1 P21453 1/20 0.32
MEN1 O00255 2/20 0.32
KMT2A Q03164 2/20 0.32
THRB P10828 1/20 0.32
HTT P42858 1/20 0.32
RECQL P46063 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25875886 0.83 KDM4E (0.37) ALDH1A1HPGDDRD2DRD4HRH2
SCHEMBL1813140 0.82 PTPN1 (0.37) PTPN1ALDH1A1DRD2DRD4HRH2
SCHEMBL25875879 0.80 PDK2 (0.39) PTPN1ALDH1A1HPGDPDK2MAPT
SCHEMBL25836761 0.79 ALDH1A1 (0.40) ALDH1A1HPGDDRD2DRD4HRH2
SCHEMBL26629591 0.78 ALDH1A1 (0.41) ALDH1A1HPGDDRD2DRD4HRH2
SCHEMBL25836790 0.77 PTPN1 (0.33) PTPN1ALDH1A1HPGDDRD2DRD4
SCHEMBL25876827 0.77 PDK2 (0.42) PDK2MEN1KMT2A
SCHEMBL25875887 0.77 KCNH2 (0.35) MAPTKDM4EMEN1KMT2A
SCHEMBL1814761 0.77 ALDH1A1 (0.36) PTPN1ALDH1A1HPGDPDK2MAPT
SCHEMBL25876872 0.76 PDK2 (0.33) PDK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023140186-A1 PHOTOCHROMIC COMPOUND, NAPHTHOL DERIVATIVE, CURABLE COMPOSITION, OPTICAL ARTICLE, LENS, AND EYEGLASSES 株式会社トクヤマ 2023-07-27 WO disclosed