Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 6/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.53 |
| ▸ | JAK1 | P23458 | 3/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | TYK2 | P29597 | 1/20 | 0.42 |
| ▸ | JAK3 | P52333 | 1/20 | 0.42 |
| ▸ | PREP | P48147 | 2/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.37 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.37 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.37 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31271385 | 0.89 | GPR119 (0.58) | GPR119HDAC1JAK1CHRM2CHRM1 | |
| SCHEMBL25313293 | 0.87 | GPR119 (0.56) | GPR119HDAC1JAK1CHRM2CHRM1 | |
| SCHEMBL31271389 | 0.83 | GPR119 (0.59) | GPR119HDAC1JAK1CHRM2CHRM1 | |
| SCHEMBL25310135 | 0.83 | GPR119 (0.59) | GPR119HDAC1JAK1CHRM2CHRM1 | |
| SCHEMBL20456691 | 0.83 | GPR119 (0.59) | GPR119HDAC1JAK1CHRM2CHRM1 | |
| SCHEMBL25309533 | 0.83 | GPR119 (0.59) | GPR119HDAC1JAK1CHRM2CHRM1 | |
| SCHEMBL31271887 | 0.82 | GPR119 (0.53) | GPR119HDAC1JAK1CHRM2CHRM1 | |
| SCHEMBL31270870 | 0.82 | GPR119 (0.56) | GPR119HDAC1JAK1CHRM2CHRM1 | |
| SCHEMBL3579478 | 0.81 | GPR119 (0.59) | GPR119HDAC1JAK1CHRM2CHRM1 | |
| SCHEMBL24962970 | 0.81 | GPR119 (0.57) | GPR119HDAC1JAK1CHRM2CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023139536-A1 | (4-PIPERAZIN-1YL)-4-ALKYL-PHTHALAZIN-1(2H)-ONE COMPOUNDS AS PARP7 INHIBITORS | RHIZEN PHARMACEUTICALS AG (CH) | 2023-07-27 | — | — | WO | disclosed |