Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 4/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12384441 | 0.83 | POLB (0.56) | POLBL3MBTL1NPSR1ALDH1A1PTPN1 | |
| SCHEMBL23325022 | 0.75 | CYP2D6 (0.36) | ALDH1A1CYP2D6CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL15125407 | 0.75 | OPRM1 (0.57) | POLBL3MBTL1NPSR1ALDH1A1CYP2D6 | |
| SCHEMBL12764374 | 0.74 | POLB (0.53) | POLBL3MBTL1NPSR1ALDH1A1CYP2D6 | |
| SCHEMBL17471229 | 0.73 | POLB (0.49) | POLBL3MBTL1NPSR1ALDH1A1PTPN1 | |
| SCHEMBL674328 | 0.73 | — | — | |
| SCHEMBL22434895 | 0.73 | POLB (0.70) | POLBL3MBTL1NPSR1ALDH1A1KMT2A | |
| SCHEMBL18199496 | 0.73 | POLB (0.70) | POLBL3MBTL1NPSR1ALDH1A1KMT2A | |
| SCHEMBL19104804 | 0.73 | POLB (0.51) | POLBL3MBTL1NPSR1ALDH1A1CYP3A4 | |
| SCHEMBL24373134 | 0.72 | KDM4E (0.45) | POLBL3MBTL1NPSR1ALDH1A1PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023116920-A1 | PENTA- FUSED HEXA-HETEROCYCLIC COMPOUND, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USE | 杭州多域生物技术有限公司 | 2023-06-29 | — | — | WO | disclosed |