SCHEMBL2587767

SCHEMBL2587767

COc1cccc(COS(N)(=O)=O)c1.[NaH]

nearest known ligand 0.60

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
IDO1 P14902 2/20 0.60
AGXT P21549 2/20 0.60
CA2 P00918 3/20 0.56
CA9 Q16790 3/20 0.56
CA1 P00915 2/20 0.56
MAOB P27338 5/20 0.53
TAAR1 Q96RJ0 3/20 0.51
CMA1 P23946 1/20 0.47
STS P08842 1/20 0.47
AOC3 Q16853 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6211173 0.85 IDO1 (0.61) IDO1AGXTMAOBTAAR1CMA1
SCHEMBL5636631 0.83 IDO1 (0.59) IDO1AGXTMAOBTAAR1CMA1
SCHEMBL6211174 0.82 IDO1 (0.57) IDO1AGXTMAOBTAAR1CMA1
SCHEMBL2591121 0.80 CA2 (0.61) IDO1CA2CA9CA1MAOB
SCHEMBL9861736 0.78 IDO1 (0.53) IDO1AGXTMAOBTAAR1CMA1
SCHEMBL9861034 0.78 IDO1 (0.53) IDO1AGXTMAOBTAAR1CMA1
SCHEMBL20478039 0.78 IDO1 (0.53) IDO1AGXTCA2MAOBTAAR1
SCHEMBL3588710 0.78 TAAR1 (0.56) IDO1AGXTCA2CA9CA1
SCHEMBL28660021 0.78 CA2 (0.73) IDO1AGXTCA2CA9CA1
Ammonia Solution, Strong SCHEMBL28351570 0.77 IDO1 (0.51) IDO1AGXTCA2MAOBTAAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20130123135-A1 Methods To Identify Modulators of TAS2R48 Receptors GIVAUDAN SA (CH) 2013-05-16 US disclosed
US-20130115624-A1 Methods To Identify Modulators GIVAUDAN S.A. (CH) 2013-05-09 US disclosed
EP-2567229-A1 METHODS TO IDENTIFY MODULATORS Givaudan SA (CH) 2013-03-13 EP disclosed
EP-2567231-A1 METHODS TO IDENTIFY MODULATORS OF TAS2R4S RECEPTORS Givaudan SA (CH) 2013-03-13 EP disclosed
WO-2011138456-A1 METHODS TO IDENTIFY MODULATORS OF TAS2R4S RECEPTORS GIVAUDAN SA (CH) 2011-11-10 WO disclosed
WO-2011138455-A1 METHODS TO IDENTIFY MODULATORS GIVAUDAN SA (CH) 2011-11-10 WO disclosed