Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 19/20 | 0.43 |
| ▸ | FLT3 | P36888 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25726418 | 0.90 | IRAK4 (0.47) | IRAK4FLT3KCNH2 | |
| SCHEMBL23539620 | 0.89 | IRAK4 (0.41) | IRAK4FLT3KCNH2PDE4B | |
| SCHEMBL23568604 | 0.89 | IRAK4 (0.41) | IRAK4FLT3KCNH2PDE4B | |
| SCHEMBL23568605 | 0.89 | IRAK4 (0.45) | IRAK4FLT3KCNH2 | |
| SCHEMBL23539873 | 0.89 | IRAK4 (0.45) | IRAK4FLT3KCNH2 | |
| SCHEMBL25878285 | 0.88 | IRAK4 (0.43) | IRAK4FLT3 | |
| SCHEMBL25878447 | 0.87 | MAPT (0.42) | — | |
| SCHEMBL25732629 | 0.85 | IRAK4 (0.45) | IRAK4FLT3 | |
| SCHEMBL25726437 | 0.84 | PDE4B (0.32) | IRAK4PDE4B | |
| SCHEMBL25878281 | 0.83 | PCSK9 (0.41) | IRAK4KCNH2PDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11707457-B2 | IRAK degraders and uses thereof | KYMERA THERAPEUTICS, INC. (US) | 2023-07-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11707457-B2 | IRAK degraders and uses thereof | IRAK2, IRAK3, IRAK1 | IRAK4 4/4885FLT3 60/4885KCNH2 4751/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.