Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 18/20 | 0.43 |
| ▸ | CRBN | Q96SW2 | 3/20 | 0.39 |
| ▸ | FLT3 | P36888 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25726427 | 0.90 | IRAK4 (0.46) | IRAK4CRBNFLT3 | |
| SCHEMBL23568609 | 0.89 | IRAK4 (0.42) | IRAK4CRBNFLT3 | |
| SCHEMBL30409519 | 0.89 | IRAK4 (0.42) | IRAK4CRBNFLT3 | |
| SCHEMBL23672394 | 0.89 | IRAK4 (0.42) | IRAK4CRBNFLT3 | |
| SCHEMBL23539543 | 0.89 | IRAK4 (0.46) | IRAK4CRBNFLT3 | |
| SCHEMBL23568608 | 0.89 | IRAK4 (0.46) | IRAK4CRBNFLT3 | |
| SCHEMBL25726460 | 0.89 | PCSK9 (0.37) | IRAK4 | |
| SCHEMBL25878276 | 0.88 | IRAK4 (0.43) | IRAK4FLT3 | |
| SCHEMBL25878447 | 0.87 | MAPT (0.42) | — | |
| SCHEMBL25878281 | 0.86 | PCSK9 (0.41) | IRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11707457-B2 | IRAK degraders and uses thereof | KYMERA THERAPEUTICS, INC. (US) | 2023-07-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11707457-B2 | IRAK degraders and uses thereof | IRAK2, IRAK3, IRAK1 | IRAK4 4/4885CRBN 187/4885FLT3 60/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.