Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K5 | Q99683 | 2/20 | 0.42 |
| ▸ | MAP4K1 | Q92918 | 4/20 | 0.39 |
| ▸ | JUN | P05412 | 2/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.36 |
| ▸ | BRAF | P15056 | 9/20 | 0.34 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.34 |
| ▸ | RAF1 | P04049 | 1/20 | 0.34 |
| ▸ | TTK | P33981 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30512123 | 0.81 | MAP4K1 (0.49) | MAP3K5MAP4K1JUNMAPK10BRAF | |
| SCHEMBL25882177 | 0.81 | MAP4K1 (0.49) | MAP3K5MAP4K1JUNMAPK10BRAF | |
| SCHEMBL25880784 | 0.81 | MAP3K5 (0.55) | MAP3K5MAP4K1BRAFROCK2PTK6 | |
| SCHEMBL25882124 | 0.77 | MAP3K5 (0.63) | MAP3K5MAP4K1BRAFRAF1ROCK2 | |
| SCHEMBL25881300 | 0.77 | MAP3K5 (0.53) | MAP3K5MAP4K1JUNMAPK10BRAF | |
| SCHEMBL30512127 | 0.77 | MAP3K5 (0.53) | MAP3K5MAP4K1JUNMAPK10BRAF | |
| SCHEMBL25879887 | 0.70 | MAP4K1 (0.42) | MAP3K5MAP4K1JUNMAPK10BRAF | |
| SCHEMBL25881914 | 0.69 | MAP3K5 (0.52) | MAP3K5MAP4K1JUNMAPK10MAPK8 | |
| SCHEMBL30512125 | 0.68 | MAP4K1 (0.59) | MAP3K5MAP4K1JUNMAPK10BRAF | |
| SCHEMBL30512131 | 0.66 | MAP3K5 (0.61) | MAP3K5MAP4K1JUNMAPK10BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023138412-A1 | FUSED PYRIMIDIN-2-AMINE COMPOUNDS AS CDK20 INHIBITORS | INSILICO MEDICINE IP LIMITED (CN) | 2023-07-27 | — | — | WO | disclosed |