Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 11/20 | 0.61 |
| ▸ | JUN | P05412 | 2/20 | 0.56 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.56 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.52 |
| ▸ | MAP3K5 | Q99683 | 2/20 | 0.50 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.47 |
| ▸ | BRAF | P15056 | 3/20 | 0.46 |
| ▸ | MAP4K3 | Q8IVH8 | 1/20 | 0.41 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30512124 | 1.00 | MAP4K1 (0.61) | MAP4K1JUNMAPK10MAPK8MAP3K5 | |
| SCHEMBL30512106 | 0.91 | MAP3K5 (0.61) | MAP4K1JUNMAPK10MAPK8MAP3K5 | |
| SCHEMBL25880788 | 0.91 | MAP3K5 (0.61) | MAP4K1JUNMAPK10MAPK8MAP3K5 | |
| SCHEMBL30512125 | 0.81 | MAP4K1 (0.59) | MAP4K1JUNMAPK10MAPK8MAP3K5 | |
| SCHEMBL1632143 | 0.78 | MAP4K1 (0.58) | MAP4K1JUNMAPK10MAPK8MAP3K5 | |
| SCHEMBL30512127 | 0.76 | MAP3K5 (0.53) | MAP4K1JUNMAPK10MAPK8MAP3K5 | |
| SCHEMBL25881300 | 0.76 | MAP3K5 (0.53) | MAP4K1JUNMAPK10MAPK8MAP3K5 | |
| SCHEMBL29576142 | 0.75 | MAP3K5 (0.59) | MAP4K1JUNMAPK10MAPK8MAP3K5 | |
| SCHEMBL30512131 | 0.74 | MAP3K5 (0.61) | MAP4K1JUNMAPK10MAPK8MAP3K5 | |
| SCHEMBL25882777 | 0.74 | MAP3K5 (0.61) | MAP4K1JUNMAPK10MAPK8MAP3K5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023138412-A1 | FUSED PYRIMIDIN-2-AMINE COMPOUNDS AS CDK20 INHIBITORS | INSILICO MEDICINE IP LIMITED (CN) | 2023-07-27 | — | — | WO | disclosed |