Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K5 | Q99683 | 2/20 | 0.61 |
| ▸ | BRAF | P15056 | 15/20 | 0.55 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.51 |
| ▸ | JUN | P05412 | 2/20 | 0.47 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.47 |
| ▸ | RAF1 | P04049 | 1/20 | 0.44 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30512106 | 1.00 | MAP3K5 (0.61) | MAP3K5BRAFMAP4K1JUNMAPK10 | |
| SCHEMBL25880624 | 0.91 | MAP4K1 (0.61) | MAP3K5BRAFMAP4K1JUNMAPK10 | |
| SCHEMBL30512124 | 0.91 | MAP4K1 (0.61) | MAP3K5BRAFMAP4K1JUNMAPK10 | |
| SCHEMBL17529301 | 0.78 | BRAF (0.49) | BRAFMAP4K1 | |
| SCHEMBL25882124 | 0.76 | MAP3K5 (0.63) | MAP3K5BRAFMAP4K1RAF1 | |
| SCHEMBL29576142 | 0.75 | MAP3K5 (0.59) | MAP3K5BRAFMAP4K1JUNMAPK10 | |
| SCHEMBL25880776 | 0.74 | MAP3K5 (0.72) | MAP3K5BRAFRAF1 | |
| SCHEMBL25881484 | 0.74 | MYLK4 (0.48) | MAP3K5BRAFMAP4K1JUNMAPK10 | |
| SCHEMBL30512125 | 0.72 | MAP4K1 (0.59) | MAP3K5BRAFMAP4K1JUNMAPK10 | |
| SCHEMBL17047457 | 0.70 | PIK3CA (0.66) | MAP3K5BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023138412-A1 | FUSED PYRIMIDIN-2-AMINE COMPOUNDS AS CDK20 INHIBITORS | INSILICO MEDICINE IP LIMITED (CN) | 2023-07-27 | — | — | WO | disclosed |