Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | CRHBP | P24387 | 2/20 | 0.52 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.42 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.41 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.41 |
| ▸ | ITGAL | P20701 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | SLC9A1 | P19634 | 3/20 | 0.35 |
| ▸ | MTNR1B | P49286 | 4/20 | 0.34 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.34 |
| ▸ | SLC9A5 | Q14940 | 1/20 | 0.33 |
| ▸ | SLC9A2 | Q9UBY0 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30485719 | 0.88 | MAP3K14 (0.47) | SMN1; SMN2LMNACRHBPCRHR2HTT | |
| SCHEMBL8081108 | 0.88 | MAP3K14 (0.47) | SMN1; SMN2LMNACRHBPCRHR2HTT | |
| SCHEMBL24367973 | 0.83 | SMN1; SMN2 (0.48) | SMN1; SMN2LMNACRHBPCRHR2HTT | |
| SCHEMBL436160 | 0.82 | MAP3K14 (0.46) | SMN1; SMN2LMNACRHBPCRHR2HTT | |
| SCHEMBL15982298 | 0.77 | SMN1; SMN2 (0.56) | SMN1; SMN2LMNACRHBPCRHR2HTT | |
| SCHEMBL15982274 | 0.77 | SMN1; SMN2 (0.56) | SMN1; SMN2LMNACRHBPCRHR2HTT | |
| SCHEMBL15982282 | 0.77 | SMN1; SMN2 (0.56) | SMN1; SMN2LMNACRHBPCRHR2HTT | |
| SCHEMBL7815996 | 0.73 | MAP3K14 (0.37) | MAP3K14ITGB2ICAM1ITGALMAOA | |
| O-Xylene SCHEMBL522767 | 0.71 | ITGB2 (0.74) | SMN1; SMN2LMNACRHBPCRHR2HTT | |
| SCHEMBL11505395 | 0.70 | LMNA (1.00) | SMN1; SMN2LMNACRHBPCRHR2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023141511-A1 | POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 | VANDERBILT UNIVERSITY (US) | 2023-07-27 | — | — | WO | disclosed |