Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Reserpine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC18A2 known ✓ | Q05940 | 1/20 | 1.00 |
| ▸ | MEN1 | O00255 | 13/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 13/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 1.00 |
| ▸ | TDP1 | Q9NUW8 | 7/20 | 1.00 |
| ▸ | TSHR | P16473 | 6/20 | 1.00 |
| ▸ | HBB | P68871 | 5/20 | 1.00 |
| ▸ | MAPT | P10636 | 5/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 4/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 1.00 |
| ▸ | USP2 | O75604 | 4/20 | 1.00 |
| ▸ | CASP1 | P29466 | 4/20 | 1.00 |
| ▸ | ALOX15 | P16050 | 4/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 3/20 | 1.00 |
| ▸ | CASP7 | P55210 | 3/20 | 1.00 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 1.00 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 1.00 |
| ▸ | OPRM1 | P35372 | 2/20 | 1.00 |
| ▸ | OPRK1 | P41145 | 2/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 2/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Reserpine SCHEMBL20402680 | 1.00 | MEN1 (1.00) | MEN1KMT2AKDM4ETDP1TSHR | |
| Reserpine SCHEMBL15385127 | 1.00 | MEN1 (1.00) | MEN1KMT2AKDM4ETDP1TSHR | |
| Isoreserpine SCHEMBL731599 | 1.00 | MEN1 (1.00) | MEN1KMT2AKDM4ETDP1TSHR | |
| Reserpine SCHEMBL1172973 | 1.00 | MEN1 (1.00) | MEN1KMT2AKDM4ETDP1TSHR | |
| Reserpine SCHEMBL4562878 | 1.00 | MEN1 (1.00) | MEN1KMT2AKDM4ETDP1TSHR | |
| Reserpine SCHEMBL12732449 | 1.00 | MEN1 (1.00) | MEN1KMT2AKDM4ETDP1TSHR | |
| Reserpine SCHEMBL8262666 | 1.00 | MEN1 (1.00) | MEN1KMT2AKDM4ETDP1TSHR | |
| Reserpine SCHEMBL14379427 | 1.00 | MEN1 (1.00) | MEN1KMT2AKDM4ETDP1TSHR | |
| Reserpine SCHEMBL5372164 | 1.00 | MEN1 (1.00) | MEN1KMT2AKDM4ETDP1TSHR | |
| Reserpine SCHEMBL22002247 | 1.00 | MEN1 (1.00) | MEN1KMT2AKDM4ETDP1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 403436 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210137854-A1 | TAAR Receptor Agonists for the Treatment of Alopecia | JUPITER WELLNESS INC. | 2021-05-13 | — | — | US | claimed |
| US-20210137883-A1 | ANTI-NEOPLASTIC COMPOUNDS AND METHODS TARGETING QSOX1 | UNIV ARIZONA STATE (US) | 2021-05-13 | — | — | US | claimed |
| EP-3476924-B1 | GREASE FOR REFRIGERATING MACHINE OIL | MITSUBISHI HEAVY IND THERMAL SYSTEMS LTD (JP) | 2021-05-12 | — | — | EP | claimed |
| EP-3591675-B1 | METHOD FOR PRODUCING HEAVY RARE EARTH GRAIN-BOUNDARY-DIFFUSED RE-FE-B-BASED RARE EARTH MAGNET | STAR GROUP IND CO LTD (KR) | 2021-05-12 | — | — | EP | claimed |
| EP-3462580-B1 | DC MOTOR WITH LIQUID RUNNING THROUGH IT | BUHLER MOTOR GMBH (DE) | 2021-05-12 | — | — | EP | claimed |
| EP-3818008-A1 | HERMETIC PACKAGE COMPRISING A GETTER, PART COMPRISING SUCH A HERMETIC PACKAGE, AND ASSOCIATED MANUFACTURING PROCESS | LYNRED (FR) | 2021-05-12 | — | — | EP | claimed |
| EP-3817689-A1 | ABUTMENT AND HEALING CUFF DEVICE FOR DENTAL IMPLANT | Finelle, Gary (FR) | 2021-05-12 | — | — | EP | claimed |
| EP-3818103-A1 | R-BASED RUBBER COMPOSITION | COMPAGNIE GENERALE DES ETABLISSEMENTS MICHELIN (FR) | 2021-05-12 | — | — | EP | claimed |
| EP-3818349-A1 | TEMPERATURE INDICATOR | SEB S.A. (FR) | 2021-05-12 | — | — | EP | claimed |
| EP-3818576-A1 | COMPOSITE ELECTROMAGNETIC SHIELDING WALL, BATTERY PACKAGING COMPRISING SUCH A WALL, AND METHOD FOR PRODUCING SUCH A WALL | Faurecia Systèmes d'Echappement (FR) | 2021-05-12 | — | — | EP | claimed |
| EP-0001665-A1 | Device for generating electricity from light | VOLVO PETROLEUM A.B. (SE) | 1979-05-02 | — | — | EP | claimed |
| EP-0000673-A1 | Process for manufacturing printed circuits with metallised holes starting from isolated substrates having a synthetic glass-resin multilayer structure | SOCIETE ANONYME DE TELECOMMUNICATIONS (S.A.T.) (FR) | 1979-02-07 | — | — | EP | claimed |
| EP-0000683-A1 | Method of producing coated glass fibres, coated fibres and their use for the reinforcement of plastics. | SAINT-GOBAIN INDUSTRIES (FR) | 1979-02-07 | — | — | EP | claimed |
| EP-0000307-A1 | Process for the construction of thin walls of various embodiments, especially of walls for channelling fluids | SAMIFER, S.R.L. (Société Auxiliaire des Mines de Fer de France) (FR) | 1979-01-10 | — | — | EP | claimed |
| US-4116949-A | WATER-SOLUBLE, PHYSIOLOGICALLY ACTIVE, SYNTHETIC COPOLYPEPTIDES | THE REAGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1978-09-26 | — | — | US | claimed |
| US-4096267-A | (1-Oxo-2-aryl or thienyl-2-substituted-5-indanyloxy (or thio) alkanoic acids, and derivatives thereof | MERCK & CO., INC. (US) | 1978-06-20 | — | — | US | claimed |
| US-4060620-A | RESERPINE | UNIVERSITY OF ILLINOIS FOUNDATION (US) | 1977-11-29 | — | — | US | claimed |
| US-3993072-A | Microporous drug delivery device | ALZA CORPORATION (US) | 1976-11-23 | — | — | US | claimed |
| US-3962455-A | Antibiotic ascofuranone and process for the production thereof | CHUGAI SEIYAKU KABUSHIKI KAISHA (JA) | 1976-06-08 | — | — | US | claimed |
| US-3952072-A | MOLDING MATERIALS | MITSUBISHI GAS CHEMICAL COMPANY, INC. (JA) | 1976-04-20 | — | — | US | claimed |