Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.37 |
| ▸ | YTHDC1 | Q96MU7 | 2/20 | 0.36 |
| ▸ | YTHDF2 | Q9Y5A9 | 2/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | XDH | P47989 | 2/20 | 0.32 |
| ▸ | RET | P07949 | 1/20 | 0.32 |
| ▸ | PI4KA | P42356 | 1/20 | 0.32 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.32 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.32 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.32 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25319103 | 0.80 | PDPK1 (0.51) | PDPK1HTR2CALDH1A1CHEK1AURKA | |
| SCHEMBL25899116 | 0.76 | HTT (0.42) | PDPK1HTTPTK2MAPTALDH1A1 | |
| Hydrazine SCHEMBL25324818 | 0.76 | PDPK1 (0.51) | PDPK1HTR2CCYP1A2ALDH1A1CHEK1 | |
| SCHEMBL15669999 | 0.75 | HTT (0.41) | PDPK1HTTPTK2CYP3A4MAPT | |
| SCHEMBL25898919 | 0.73 | RET (0.47) | PDPK1HTTPTK2CYP1A2MAPT | |
| SCHEMBL25669076 | 0.70 | HTT (0.37) | PDPK1HTTPTK2MAPTALDH1A1 | |
| SCHEMBL10094590 | 0.69 | PDPK1 (1.00) | PDPK1PTK2CYP1A2ALDH1A1CHEK1 | |
| SCHEMBL25049606 | 0.68 | KDM4E (0.42) | CYP1A2CYP3A4MAPTALDH1A1LRRK2 | |
| SCHEMBL6127809 | 0.67 | MAPT (0.48) | HTTPTK2CYP1A2MAPTALDH1A1 | |
| SCHEMBL25003204 | 0.67 | CYP1A2 (0.45) | PDPK1CYP1A2CYP3A4CYP2D6ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023146991-A1 | COMPOUNDS AND METHODS OF USE | TANGO THERAPEUTICS, INC. (US) | 2023-08-03 | — | — | WO | disclosed |
| WO-2023146990-A1 | COMPOUNDS AND METHODS OF USE | TANGO THERAPEUTICS, INC. (US) | 2023-08-03 | — | — | WO | disclosed |