Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.33 |
| ▸ | METAP2 | P50579 | 1/20 | 0.33 |
| ▸ | XDH | P47989 | 2/20 | 0.32 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.32 |
| ▸ | AURKA | O14965 | 1/20 | 0.32 |
| ▸ | RET | P07949 | 1/20 | 0.32 |
| ▸ | PI4KA | P42356 | 1/20 | 0.32 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.32 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.32 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.32 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.32 |
| ▸ | DRD1 | P21728 | 3/20 | 0.32 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.32 |
| ▸ | BRAF | P15056 | 1/20 | 0.32 |
| ▸ | EIF2AK3 | Q9NZJ5 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15669999 | 0.81 | HTT (0.41) | HTTPTK2MAPTIDO1ALDH1A1 | |
| SCHEMBL16830110 | 0.79 | NOS1 (0.41) | HTTPTK2MAPTIDO1ALDH1A1 | |
| SCHEMBL25919746 | 0.79 | NOS1 (0.41) | HTTPTK2MAPTIDO1ALDH1A1 | |
| SCHEMBL25898919 | 0.79 | RET (0.47) | HTTPTK2MAPTIDO1ALDH1A1 | |
| SCHEMBL26204680 | 0.78 | HSP90AA1 (0.36) | HTTPTK2MAPTIDO1ALDH1A1 | |
| SCHEMBL25899017 | 0.76 | PDPK1 (0.53) | HTTPTK2MAPTALDH1A1PDPK1 | |
| SCHEMBL16276755 | 0.73 | HTT (0.40) | HTTPTK2MAPTIDO1ALDH1A1 | |
| SCHEMBL6127809 | 0.73 | MAPT (0.48) | HTTPTK2MAPTIDO1ALDH1A1 | |
| SCHEMBL20674133 | 0.71 | HTT (0.35) | HTTPTK2MAPTIDO1ALDH1A1 | |
| SCHEMBL25899020 | 0.71 | MAPT (0.43) | HTTPTK2MAPTIDO1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023146991-A1 | COMPOUNDS AND METHODS OF USE | TANGO THERAPEUTICS, INC. (US) | 2023-08-03 | — | — | WO | disclosed |
| WO-2023146990-A1 | COMPOUNDS AND METHODS OF USE | TANGO THERAPEUTICS, INC. (US) | 2023-08-03 | — | — | WO | disclosed |
| WO-2023146987-A1 | COMPOUNDS AND METHODS OF USE | TANGO THERAPEUTICS, INC. (US) | 2023-08-03 | — | — | WO | disclosed |