Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DOT1L | Q8TEK3 | 13/20 | 0.61 |
| ▸ | PRMT1 | Q99873 | 2/20 | 0.60 |
| ▸ | HINT1 | P49773 | 1/20 | 0.59 |
| ▸ | DNMT3B | Q9UBC3 | 5/20 | 0.58 |
| ▸ | DNMT1 | P26358 | 4/20 | 0.56 |
| ▸ | CARM1 | Q86X55 | 2/20 | 0.56 |
| ▸ | EHMT2 | Q96KQ7 | 2/20 | 0.56 |
| ▸ | TRDMT1 | O14717 | 1/20 | 0.56 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.56 |
| ▸ | SUV39H1 | O43463 | 1/20 | 0.56 |
| ▸ | PRMT3 | O60678 | 1/20 | 0.56 |
| ▸ | INMT | O95050 | 1/20 | 0.56 |
| ▸ | NSD2 | O96028 | 1/20 | 0.56 |
| ▸ | PNMT | P11086 | 1/20 | 0.56 |
| ▸ | NNMT | P40261 | 1/20 | 0.56 |
| ▸ | HNMT | P50135 | 1/20 | 0.56 |
| ▸ | WDR5 | P61964 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | SETDB1 | Q15047 | 1/20 | 0.56 |
| ▸ | RBBP5 | Q15291 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21553891 | 1.00 | DOT1L (0.61) | DOT1LPRMT1HINT1DNMT3BDNMT1 | |
| SCHEMBL21553970 | 0.96 | DOT1L (0.58) | DOT1LPRMT1HINT1DNMT3BDNMT1 | |
| SCHEMBL21553884 | 0.96 | DOT1L (0.59) | DOT1LPRMT1HINT1DNMT3BDNMT1 | |
| SCHEMBL18119946 | 0.85 | HINT1 (0.68) | DOT1LPRMT1HINT1DNMT3BDNMT1 | |
| SCHEMBL25899392 | 0.83 | HINT1 (0.53) | DOT1LHINT1 | |
| SCHEMBL25899380 | 0.82 | DOT1L (0.57) | DOT1LPRMT1DNMT3BDNMT1CARM1 | |
| SCHEMBL21553885 | 0.82 | HINT1 (0.64) | DOT1LPRMT1HINT1DNMT3BDNMT1 | |
| SCHEMBL21553923 | 0.82 | HINT1 (0.59) | HINT1EZH2 | |
| SCHEMBL30520257 | 0.82 | HINT1 (0.63) | DOT1LPRMT1HINT1DNMT3BDNMT1 | |
| SCHEMBL21528355 | 0.82 | HINT1 (0.63) | DOT1LPRMT1HINT1DNMT3BDNMT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4219518-A2 | BIOCONJUGATES OF HETEROCYCLIC COMPOUNDS | Taizhou Huifeng Hetai Biotechnology Co. Ltd (CN) | 2023-08-02 | — | — | EP | disclosed |