Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VHL | P40337 | 17/20 | 0.60 |
| ▸ | SMARCA2 | P51531 | 4/20 | 0.46 |
| ▸ | SMARCA4 | P51532 | 4/20 | 0.46 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.40 |
| ▸ | ELOC | Q15369 | 3/20 | 0.39 |
| ▸ | ELOB | Q15370 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25893329 | 0.91 | VHL (0.57) | VHLSMARCA2SMARCA4SOS1ELOC | |
| SCHEMBL34469717 | 0.90 | VHL (0.61) | VHLSMARCA2SMARCA4SOS1ELOC | |
| SCHEMBL21456393 | 0.89 | VHL (0.64) | VHLSMARCA2SMARCA4ELOCELOB | |
| SCHEMBL21456410 | 0.89 | VHL (0.60) | VHLSMARCA2SMARCA4SOS1ELOC | |
| SCHEMBL21456404 | 0.89 | VHL (0.60) | VHLSMARCA2SMARCA4ELOCELOB | |
| SCHEMBL23205395 | 0.89 | VHL (0.60) | VHLSMARCA2SMARCA4ELOCELOB | |
| SCHEMBL23205572 | 0.89 | VHL (0.60) | VHLSMARCA2SMARCA4SOS1ELOC | |
| SCHEMBL24870169 | 0.88 | VHL (0.54) | VHLSMARCA2SMARCA4SOS1 | |
| SCHEMBL24757893 | 0.88 | VHL (0.54) | VHLSMARCA2SMARCA4SOS1 | |
| SCHEMBL23205220 | 0.88 | VHL (0.59) | VHLSMARCA2SMARCA4SOS1ELOC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023141570-A2 | COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF KRAS | ARVINAS OPERATIONS, INC. (US) | 2023-07-27 | — | — | WO | disclosed |