Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EZH2 | Q15910 | 16/20 | 0.52 |
| ▸ | EZH1 | Q92800 | 5/20 | 0.51 |
| ▸ | EED | O75530 | 4/20 | 0.47 |
| ▸ | SUZ12 | Q15022 | 4/20 | 0.47 |
| ▸ | RBBP4 | Q09028 | 3/20 | 0.47 |
| ▸ | AEBP2 | Q6ZN18 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12180171 | 0.95 | EZH2 (0.53) | EZH2EZH1EEDSUZ12RBBP4 | |
| SCHEMBL2594076 | 0.90 | EZH2 (0.60) | EZH2EZH1EEDSUZ12RBBP4 | |
| SCHEMBL2587499 | 0.88 | EZH2 (0.64) | EZH2EZH1EEDSUZ12RBBP4 | |
| SCHEMBL12180132 | 0.85 | EZH2 (0.54) | EZH2EZH1EEDSUZ12RBBP4 | |
| SCHEMBL19621000 | 0.85 | EZH2 (0.54) | EZH2EZH1EEDSUZ12RBBP4 | |
| SCHEMBL16360815 | 0.85 | EZH2 (0.54) | EZH2EZH1EEDSUZ12RBBP4 | |
| SCHEMBL12180092 | 0.85 | EZH2 (0.56) | EZH2EZH1EEDSUZ12RBBP4 | |
| SCHEMBL17584933 | 0.84 | EZH2 (0.53) | EZH2EZH1EEDSUZ12RBBP4 | |
| SCHEMBL2594866 | 0.84 | EZH2 (0.67) | EZH2EZH1EEDSUZ12RBBP4 | |
| SCHEMBL12180100 | 0.84 | EZH2 (0.53) | EZH2EZH1EEDSUZ12RBBP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2566327-A1 | INDOLES | GlaxoSmithKline LLC (US) | 2013-03-13 | — | — | EP | claimed |
| WO-2011140324-A1 | INDOLES | GLAXOSMITHKLINE LLC (US) | 2011-11-10 | — | — | WO | claimed |