Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EZH2 | Q15910 | 15/20 | 0.60 |
| ▸ | EED | O75530 | 4/20 | 0.56 |
| ▸ | SUZ12 | Q15022 | 4/20 | 0.56 |
| ▸ | RBBP4 | Q09028 | 3/20 | 0.56 |
| ▸ | AEBP2 | Q6ZN18 | 3/20 | 0.56 |
| ▸ | EZH1 | Q92800 | 7/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2594866 | 0.95 | EZH2 (0.67) | EZH2EEDSUZ12RBBP4AEBP2 | |
| SCHEMBL12180072 | 0.92 | EZH2 (0.58) | EZH2EEDSUZ12RBBP4AEBP2 | |
| SCHEMBL2590225 | 0.90 | EZH2 (0.52) | EZH2EEDSUZ12RBBP4AEBP2 | |
| SCHEMBL2592559 | 0.88 | EZH2 (0.64) | EZH2EEDSUZ12RBBP4AEBP2 | |
| SCHEMBL30620946 | 0.88 | EZH2 (0.64) | EZH2EEDSUZ12RBBP4AEBP2 | |
| SCHEMBL12180167 | 0.87 | EZH2 (0.61) | EZH2EEDSUZ12RBBP4AEBP2 | |
| SCHEMBL12180138 | 0.86 | EZH2 (0.65) | EZH2EEDSUZ12RBBP4AEBP2 | |
| SCHEMBL2593214 | 0.86 | EZH2 (0.65) | EZH2EEDSUZ12RBBP4AEBP2 | |
| SCHEMBL2591080 | 0.86 | EZH2 (0.56) | EZH2EEDSUZ12RBBP4AEBP2 | |
| SCHEMBL19621000 | 0.85 | EZH2 (0.54) | EZH2EEDSUZ12RBBP4AEBP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2566327-A1 | INDOLES | GlaxoSmithKline LLC (US) | 2013-03-13 | — | — | EP | claimed |
| WO-2011140324-A1 | INDOLES | GLAXOSMITHKLINE LLC (US) | 2011-11-10 | — | — | WO | claimed |