Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 8/20 | 0.43 |
| ▸ | MAOB | P27338 | 8/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA6 | P23280 | 1/20 | 0.41 |
| ▸ | CA5A | P35218 | 1/20 | 0.41 |
| ▸ | CA7 | P43166 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.41 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.41 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25903921 | 0.87 | PDK2 (0.43) | MAOAMAOBCA12CA1CA2 | |
| SCHEMBL30506984 | 0.87 | MAOA (0.40) | MAOAMAOBCYP3A4MAPTNPC1 | |
| SCHEMBL25317632 | 0.87 | MAOA (0.40) | MAOAMAOBCYP3A4MAPTNPC1 | |
| SCHEMBL26029590 | 0.84 | PDK2 (0.36) | MAOAMAOBCYP3A4CA12CA1 | |
| SCHEMBL25317399 | 0.81 | MAOB (0.55) | MAOAMAOBCA12CA1CA2 | |
| SCHEMBL26023399 | 0.74 | AVPR1A (0.47) | CA1CA2CA7CA9KDM4E | |
| SCHEMBL1993746 | 0.72 | CA12 (0.39) | MAOAMAOBCYP3A4CA12CA1 | |
| SCHEMBL13709098 | 0.72 | CYP3A4 (0.47) | CYP3A4PDK2ALDH1A1HPGDTSHR | |
| SCHEMBL31394738 | 0.71 | AVPR1A (0.47) | CA1CA2CA7CA9L3MBTL1 | |
| SCHEMBL25313161 | 0.71 | AVPR1A (0.47) | MAOAMAOBCYP3A4CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023141432-A2 | APOL1 INHIBITORS AND METHODS OF USE | MAZE THERAPEUTICS, INC. (US) | 2023-07-27 | — | — | WO | disclosed |